ICD-10-CM 2027
ICD-10 code for Cachexia
From the official ICD-10-CM alphabetic index entry “Cachexia”. Page updated September 29, 2026.
About coding Cachexia
The ICD-10-CM code for Cachexia is R64 (Cachexia). The official index lists 16 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on R64.
Don't report R64 together with the conditions in its Excludes1 note: abnormal weight loss (R63.4), cachexia due to underlying condition (E88.A) and nutritional marasmus (E41).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 947 (Signs and Symptoms with MCC, relative weight 1.261) and DRG 948 (Signs and Symptoms without MCC, relative weight 0.7835), in MDC 23 (Factors Influencing Health Status and Other Contacts with Health Services), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific Cachexia codes (official index)
- cancerous R64 — Cachexia
- cardiac
- dehydration E86.0 — Dehydration
- due to
- malnutrition E88.A — Wasting disease (syndrome) due to underlying condition
- underlying condition E88.A — Wasting disease (syndrome) due to underlying condition
- exophthalmic
- heart
- hypophyseal E23.0 — Hypopituitarism
- hypopituitary E23.0 — Hypopituitarism
- lead
- malignant R64 — Cachexia
- marsh
- nervous F48.8 — Other specified nonpsychotic mental disorders
- old age R54 — Age-related physical debility
- paludal
- pituitary E23.0 — Hypopituitarism
- pulmonary R64 — Cachexia
- renal N28.9 — Disorder of kidney and ureter, unspecified
- saturnine
- senile R54 — Age-related physical debility
- Simmonds' E23.0 — Hypopituitarism
- splenica D73.0 — Hyposplenism
- strumipriva E03.4 — Atrophy of thyroid (acquired)
- tuberculous NEC
Don't confuse with (Excludes1 for R64)
Common questions about Cachexia ICD-10 codes
What is the ICD-10 code for Cachexia?
- R64 — Cachexia. More specific codes apply when the documentation supports them: R64, E86.0, E88.A, E88.A and others below.
What is the ICD-10 code for cancerous cachexia?
- R64 — Cachexia.
What is the ICD-10 code for dehydration cachexia?
- E86.0 — Dehydration.
What is the ICD-10 code for hypophyseal cachexia?
- E23.0 — Hypopituitarism.
What is the ICD-10 code for hypopituitary cachexia?
- E23.0 — Hypopituitarism.
What is the ICD-10 code for malignant cachexia?
- R64 — Cachexia.
What is the ICD-10 code for nervous cachexia?
- F48.8 — Other specified nonpsychotic mental disorders.
Is R64 billable?
- Yes. R64 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can R64 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict R64 as a principal diagnosis.
Is R64 a CC or MCC?
- R64 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.