E23.0Hypopituitarism

E23.0 is the ICD-10-CM diagnosis code for hypopituitarism. It belongs to category E23 (hypofunction and other disorders of the pituitary gland), block E20-E35 (disorders of other endocrine glands) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E23 (hypofunction and other disorders of the pituitary gland), E23.0 is specifically for hypopituitarism. Related codes cover drug-induced hypopituitarism (E23.1), diabetes insipidus (E23.2), hypothalamic dysfunction, not elsewhere classified (E23.3), other disorders of pituitary gland (E23.6) and disorder of pituitary gland, unspecified (E23.7).

Use an additional code, if applicable, for associated cachexia (E88.A).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 253.2 (Panhypopituitarism), 253.3 (pituitary dwarfism) and 628.1 (infertility, female, of pituitary-hypothalamic origin).