E88.AWasting disease (syndrome) due to underlying condition

E88.A is the ICD-10-CM diagnosis code for wasting disease (syndrome) due to underlying condition. It belongs to category E88 (other and unspecified metabolic disorders), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E88 (other and unspecified metabolic disorders), E88.A is specifically for wasting disease (syndrome) due to underlying condition. Related codes cover disorders of plasma-protein metabolism, not elsewhere classified (E88.0), lipodystrophy, not elsewhere classified (E88.1), Lipomatosis, not elsewhere classified (E88.2), tumor lysis syndrome (E88.3), mitochondrial metabolism disorders (E88.4), other specified metabolic disorders (E88.8) and metabolic disorder, unspecified (E88.9).

Don't report E88.A together with the conditions in its Excludes1 note: cachexia NOS (R64) and nutritional marasmus (E41).

The conditions in its Excludes2 note aren't part of E88.A, but may be coded alongside it if the patient has both: failure to thrive (R62.51, R62.7).

Code first: underlying condition.

Use an additional code for: codes for associated conditions.

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.

It was added in FY2024, effective October 1, 2023.