ICD-10-CM 2027
ICD-10 code for chronic fatigue
From the official ICD-10-CM alphabetic index entry “Fatigue › chronic”. Page updated September 29, 2026.
About coding chronic fatigue
The ICD-10-CM code for chronic fatigue is R53.82 (Chronic fatigue, unspecified).
Within R53.8, choose R53.82 (Chronic fatigue, unspecified) only when documentation doesn't support a more specific option: other malaise (R53.81) and other fatigue (R53.83).
Don't report R53.82 together with the conditions in its Excludes1 note: chronic fatigue syndrome (G93.32), myalgic encephalomyelitis (G93.32), other post infection and related fatigue syndromes (G93.39) and postviral fatigue syndrome (G93.31).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
Don't confuse with (Excludes1 for R53.82)
Common questions about chronic fatigue ICD-10 codes
What is the ICD-10 code for chronic fatigue?
- R53.82 — Chronic fatigue, unspecified.
Is R53.82 billable?
- Yes. R53.82 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can R53.82 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict R53.82 as a principal diagnosis.
Is R53.82 a CC or MCC?
- No. R53.82 is neither a CC nor an MCC under MS-DRG v44.0.