ICD-10-CM 2027
ICD-10 code for Hemoglobinopathy
From the official ICD-10-CM alphabetic index entry “Hemoglobinopathy (mixed)”. Page updated September 29, 2026.
About coding Hemoglobinopathy
The ICD-10-CM code for Hemoglobinopathy is D58.2 (Other hemoglobinopathies). The official index lists 11 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on D58.2.
Within D58, choose D58.2 (Other hemoglobinopathies) only when documentation doesn't support a more specific option: hereditary spherocytosis (D58.0), hereditary elliptocytosis (D58.1), other specified hereditary hemolytic anemias (D58.8) and hereditary hemolytic anemia, unspecified (D58.9).
Don't report D58.2 together with the conditions in its Excludes1 note: familial polycythemia (D75.0), Hb-M disease (D74.0), hemoglobin E-beta thalassemia (D56.5), hereditary persistence of fetal hemoglobin [HPFH] (D56.4) and 3 more.
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
More specific Hemoglobinopathy codes (official index)
- with thalassemia D56.8 — Other thalassemias
- sickle-cell D57.1 — Sickle-cell disease without crisis
- with thalassemia D57.40 — Sickle-cell thalassemia without crisis
- with
- acute chest syndrome D57.411 — Sickle-cell thalassemia, unspecified, with acute chest syndrome
- cerebral vascular involvement D57.413 — Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
- crisis (painful) D57.419 — Sickle-cell thalassemia, unspecified, with crisis
- with
- dactylitis D57.414 — Sickle-cell thalassemia, unspecified, with dactylitis
- specified complication NEC D57.418 — Sickle-cell thalassemia, unspecified, with crisis with other specified complication
- pain (vaso-occlusive) D57.419 — Sickle-cell thalassemia, unspecified, with crisis
- splenic sequestration D57.412 — Sickle-cell thalassemia, unspecified, with splenic sequestration
- without crisis D57.40 — Sickle-cell thalassemia without crisis
Don't confuse with (Excludes1 for D58.2)
Common questions about Hemoglobinopathy ICD-10 codes
What is the ICD-10 code for Hemoglobinopathy?
- D58.2 — Other hemoglobinopathies. More specific codes apply when the documentation supports them: D56.8, D57.1, D57.40, D57.411 and others below.
What is the ICD-10 code for sickle-cell hemoglobinopathy?
- D57.1 — Sickle-cell disease without crisis.
Is D58.2 billable?
- Yes. D58.2 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D58.2 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D58.2 as a principal diagnosis.
Is D58.2 a CC or MCC?
- No. D58.2 is neither a CC nor an MCC under MS-DRG v44.0.