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ICD-10-CM 2027 diagnosis code

D57.412Sickle-cell thalassemia, unspecified, with splenic sequestration

✓ Billable / specificMCC — major complication/comorbidity

D57.412 is a valid, billable ICD-10-CM code for sickle-cell thalassemia, unspecified, with splenic sequestration. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Sickle-cell thalassemia, unsp, with splenic sequestration

Code last changed in FY2021 (effective October 1, 2020). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About D57.412

D57.412 is the ICD-10-CM diagnosis code for sickle-cell thalassemia, unspecified, with splenic sequestration. It belongs to category D57 (sickle-cell disorders), block D55-D59 (hemolytic anemias) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within D57.41 (sickle-cell thalassemia, unspecified, with crisis), D57.412 is specifically for sickle-cell thalassemia, unspecified, with splenic sequestration. Related codes cover acute chest syndrome (D57.411), cerebral vascular involvement (D57.413), dactylitis (D57.414), with other specified complication (D57.418) and crisis (D57.419).

Use an additional code for any associated fever (R50.81).

As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 791 (Prematurity with Major Problems, relative weight 4.1075), DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), DRG 811 (Red Blood Cell Disorders with MCC, relative weight 1.3988) and DRG 812 (Red Blood Cell Disorders without MCC, relative weight 0.9234), in MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period) and MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015, and changed in FY2021 (title revised).

Before ICD-10, this condition was coded in ICD-9-CM as 282.42 (sickle-cell thalassemia with crisis) and 289.52 (splenic sequestration).

Notes that apply from higher levels

Instructions written at a parent level also apply to D57.412.

› From D57 Sickle-cell disorders
Excludes1
  • other hemoglobinopathies (D58.-)
Use additional code
  • code for any associated fever (R50.81)

Broader instructions also apply from Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism.

Alphabetic index entries

3 entries

Terms in the official ICD-10-CM index that lead to D57.412.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

MDC 15 · Newborns and Other Neonates with Conditions Originating in the Perinatal Period

MDC 15 · Newborns and Other Neonates with Conditions Originating in the Perinatal Period

MDC 16 · Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders

ICD-9-CM equivalent

Converter →
  • 282.42Sickle-cell thalassemia with crisisapproximate, combination
  • 289.52Splenic sequestrationapproximate, combination

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • FY2021 (effective 10/1/2020): Title revised — was “Sickle-cell thalassemia with splenic sequestration”

Common questions about D57.412

Is D57.412 billable?

Yes. D57.412 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can D57.412 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict D57.412 as a principal diagnosis.

Is D57.412 a CC or MCC?

D57.412 is an MCC (major complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.

What DRG does D57.412 group to?

D57.412 is used in the MS-DRG v44.0 logic for MS-DRG 791 (Prematurity with Major Problems), MS-DRG 793 (Full Term Neonate with Major Problems), MS-DRG 811 (Red Blood Cell Disorders with MCC) and MS-DRG 812 (Red Blood Cell Disorders without MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for D57.412?

The CMS General Equivalence Mappings map D57.412 to ICD-9-CM 282.42 and 289.52.