ICD-10-CM 2027
ICD-10 code for Hypergastrinemia
From the official ICD-10-CM alphabetic index entry “Hypergastrinemia”. Page updated September 29, 2026.
About coding Hypergastrinemia
The ICD-10-CM code for Hypergastrinemia is E16.4 (Increased secretion of gastrin).
Within E16 (other disorders of pancreatic internal secretion), E16.4 is specifically for increased secretion of gastrin. Related codes cover drug-induced hypoglycemia without coma (E16.0), other hypoglycemia (E16.1), hypoglycemia, unspecified (E16.2), increased secretion of glucagon (E16.3), other specified disorders of pancreatic internal secretion (E16.8), disorder of pancreatic internal secretion, unspecified (E16.9) and hypoglycemia level (E16.A).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 380 (Complicated Peptic Ulcer with MCC, relative weight 1.9245), DRG 381 (Complicated Peptic Ulcer with CC, relative weight 1.0838) and DRG 382 (Complicated Peptic Ulcer without CC/MCC, relative weight 0.7281), in MDC 06 (Diseases and Disorders of the Digestive System), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about Hypergastrinemia ICD-10 codes
What is the ICD-10 code for Hypergastrinemia?
- E16.4 — Increased secretion of gastrin.
Is E16.4 billable?
- Yes. E16.4 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E16.4 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E16.4 as a principal diagnosis.
Is E16.4 a CC or MCC?
- No. E16.4 is neither a CC nor an MCC under MS-DRG v44.0.