ICD-10-CM 2027
ICD-10 code for irritable
From the official ICD-10-CM alphabetic index entry “Irritable, irritability”. Page updated September 29, 2026.
About coding irritable
The ICD-10-CM code for irritable is R45.4 (Irritability and anger). The official index lists 22 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on R45.4.
Within R45 (symptoms and signs involving emotional state), R45.4 is specifically for irritability and anger. Related codes cover Nervousness (R45.0), Restlessness and agitation (R45.1), unhappiness (R45.2), Demoralization and apathy (R45.3), Hostility (R45.5), Violent behavior (R45.6), state of emotional shock and stress, unspecified (R45.7) and other symptoms and signs involving emotional state (R45.8).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 880 (Acute Adjustment Reaction and Psychosocial Dysfunction, relative weight 0.9306), in MDC 19 (Mental Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific irritable codes (official index)
- bladder N32.89 — Other specified disorders of bladder
- bowel (syndrome) K58.9 — Irritable bowel syndrome, unspecified
- with
- constipation K58.1 — Irritable bowel syndrome with constipation
- diarrhea K58.0 — Irritable bowel syndrome with diarrhea
- mixed K58.2 — Mixed irritable bowel syndrome
- psychogenic F45.8 — Other somatoform disorders
- specified NEC K58.8 — Other irritable bowel syndrome
- without diarrhea K58.9 — Irritable bowel syndrome, unspecified
- bronchial
- cerebral, in newborn P91.3 — Neonatal cerebral irritability
- colon K58.9 — Irritable bowel syndrome, unspecified
- with diarrhea K58.0 — Irritable bowel syndrome with diarrhea
- psychogenic F45.8 — Other somatoform disorders
- duodenum K59.89 — Other specified functional intestinal disorders
- heart (psychogenic) F45.8 — Other somatoform disorders
- hip
- ileum K59.89 — Other specified functional intestinal disorders
- infant R68.12 — Fussy infant (baby)
- jejunum K59.89 — Other specified functional intestinal disorders
- rectum K59.89 — Other specified functional intestinal disorders
- stomach K31.89 — Other diseases of stomach and duodenum
- psychogenic F45.8 — Other somatoform disorders
- sympathetic G90.89 — Other disorders of autonomic nervous system
- urethra N36.8 — Other specified disorders of urethra
Common questions about irritable ICD-10 codes
What is the ICD-10 code for irritable?
- R45.4 — Irritability and anger. More specific codes apply when the documentation supports them: N32.89, K58.9, K58.1, K58.0 and others below.
What is the ICD-10 code for bladder irritable?
- N32.89 — Other specified disorders of bladder.
What is the ICD-10 code for bowel irritable?
- K58.9 — Irritable bowel syndrome, unspecified.
What is the ICD-10 code for colon irritable?
- K58.9 — Irritable bowel syndrome, unspecified.
What is the ICD-10 code for duodenum irritable?
- K59.89 — Other specified functional intestinal disorders.
What is the ICD-10 code for heart irritable?
- F45.8 — Other somatoform disorders.
What is the ICD-10 code for ileum irritable?
- K59.89 — Other specified functional intestinal disorders.
Is R45.4 billable?
- Yes. R45.4 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can R45.4 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict R45.4 as a principal diagnosis.
Is R45.4 a CC or MCC?
- No. R45.4 is neither a CC nor an MCC under MS-DRG v44.0.