ICD-10-CM 2027
ICD-10 code for Leigh's disease
From the official ICD-10-CM alphabetic index entry “Leigh's disease”. Page updated September 29, 2026.
About coding Leigh's disease
The ICD-10-CM code for Leigh's disease is G31.82 (Leigh's disease).
Within G31.8 (other specified degenerative diseases of nervous system), G31.82 is specifically for Leigh's disease. Related codes cover leukodystrophy, unspecified (G31.80), Alpers disease (G31.81), neurocognitive disorder with Lewy bodies (G31.83), mild cognitive impairment of uncertain or unknown etiology (G31.84), Corticobasal degeneration (G31.85), Alexander disease (G31.86), primary progressive apraxia of speech (G31.87) and other specified degenerative diseases of nervous system (G31.89).
Use an additional code, if applicable, for codes G31.0-G31.83, G31.85-G31.9, to identify: dementia with anxiety (F02.84, F02.A4, F02.B4, F02.C4), dementia with behavioral disturbance (F02.81-, F02.A1-, F02.B1-, F02.C1-), dementia with mood disturbance (F02.83, F02.A3, F02.B3, F02.C3), dementia with psychotic disturbance (F02.82, F02.A2, F02.B2, F02.C2), dementia without behavioral disturbance (F02.80, F02.A0, F02.B0, F02.C0) and 1 more.
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
Common questions about Leigh's disease ICD-10 codes
What is the ICD-10 code for Leigh's disease?
- G31.82 — Leigh's disease.
Is G31.82 billable?
- Yes. G31.82 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can G31.82 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict G31.82 as a principal diagnosis.
Is G31.82 a CC or MCC?
- G31.82 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.