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ICD-10-CM 2027 diagnosis code

G31.81Alpers disease

✓ Billable / specificCC — complication/comorbidity

G31.81 is a valid, billable ICD-10-CM code for alpers disease. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Looking up by condition? See ICD-10 code for Alpers' disease.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About G31.81

G31.81 is the ICD-10-CM diagnosis code for Alpers disease. It belongs to category G31 (other degenerative diseases of nervous system, not elsewhere classified), block G30-G32 (other degenerative diseases of the nervous system) and chapter 6 (diseases of the nervous system). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within G31.8 (other specified degenerative diseases of nervous system), G31.81 is specifically for Alpers disease. Related codes cover leukodystrophy, unspecified (G31.80), Leigh's disease (G31.82), neurocognitive disorder with Lewy bodies (G31.83), mild cognitive impairment of uncertain or unknown etiology (G31.84), Corticobasal degeneration (G31.85), Alexander disease (G31.86), primary progressive apraxia of speech (G31.87) and other specified degenerative diseases of nervous system (G31.89).

Use an additional code, if applicable, for codes G31.0-G31.83, G31.85-G31.9, to identify: dementia with anxiety (F02.84, F02.A4, F02.B4, F02.C4), dementia with behavioral disturbance (F02.81-, F02.A1-, F02.B1-, F02.C1-), dementia with mood disturbance (F02.83, F02.A3, F02.B3, F02.C3), dementia with psychotic disturbance (F02.82, F02.A2, F02.B2, F02.C2), dementia without behavioral disturbance (F02.80, F02.A0, F02.B0, F02.C0) and 1 more.

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 056 (Degenerative Nervous System Disorders with MCC, relative weight 2.2655) and DRG 057 (Degenerative Nervous System Disorders without MCC, relative weight 1.2838), in MDC 01 (Diseases and Disorders of the Nervous System), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 330.8 (other specified cerebral degenerations in childhood).

Coding notes

Applicable toConditions and synonyms classified to this code
  • Grey-matter degeneration

Notes that apply from higher levels

Instructions written at a parent level also apply to G31.81.

› From G31 Other degenerative diseases of nervous system, not elsewhere classified
Excludes2
Use additional code

Broader instructions also apply from Chapter 6: Diseases of the nervous system.

Alphabetic index entries

2 entries

Terms in the official ICD-10-CM index that lead to G31.81.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

ICD-9-CM equivalent

Converter →
  • 330.8Other specified cerebral degenerations in childhoodapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about G31.81

Is G31.81 billable?

Yes. G31.81 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can G31.81 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict G31.81 as a principal diagnosis.

Is G31.81 a CC or MCC?

G31.81 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.

What DRG does G31.81 group to?

G31.81 is used in the MS-DRG v44.0 logic for MS-DRG 056 (Degenerative Nervous System Disorders with MCC) and MS-DRG 057 (Degenerative Nervous System Disorders without MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for G31.81?

The CMS General Equivalence Mappings map G31.81 to ICD-9-CM 330.8.