ICD-10-CM 2027
ICD-10 code for Lepore trait
From the official ICD-10-CM alphabetic index entry “Trait (s) › Lepore”. Page updated September 29, 2026.
About coding Lepore trait
The ICD-10-CM code for Lepore trait is D56.3 (Thalassemia minor).
Within D56 (thalassemia), D56.3 is specifically for thalassemia minor. Related codes cover alpha thalassemia (D56.0), beta thalassemia (D56.1), Delta-beta thalassemia (D56.2), hereditary persistence of fetal hemoglobin [HPFH] (D56.4), hemoglobin E-beta thalassemia (D56.5), other thalassemias (D56.8) and unspecified (D56.9).
Don't report D56.3 together with the conditions in its Excludes1 note: alpha thalassemia (D56.0), beta thalassemia (D56.1), delta-beta thalassemia (D56.2), hemoglobin E-beta thalassemia (D56.5) and 1 more.
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
Don't confuse with (Excludes1 for D56.3)
Common questions about Lepore trait ICD-10 codes
What is the ICD-10 code for Lepore trait?
- D56.3 — Thalassemia minor.
Is D56.3 billable?
- Yes. D56.3 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D56.3 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D56.3 as a principal diagnosis.
Is D56.3 a CC or MCC?
- No. D56.3 is neither a CC nor an MCC under MS-DRG v44.0.