ICD-10-CM 2027
ICD-10 code for leukoencephalopathy
From the official ICD-10-CM alphabetic index entry “Leukoencephalopathy”. Page updated September 29, 2026.
About coding leukoencephalopathy
The ICD-10-CM code for leukoencephalopathy is G93.49 (Other encephalopathy). The official index lists 14 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on G93.49.
Within G93.4, choose G93.49 (Other encephalopathy) only when documentation doesn't support a more specific option: encephalopathy, unspecified (G93.40), metabolic encephalopathy (G93.41), Megalencephalic leukoencephalopathy with subcortical cysts (G93.42), leukoencephalopathy with calcifications and cysts (G93.43), Adult-onset leukodystrophy with axonal spheroids (G93.44) and developmental and epileptic encephalopathy (G93.45).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 070 (Other Cerebrovascular Disorders with MCC, relative weight 1.6093), DRG 071 (Other Cerebrovascular Disorders with CC, relative weight 1.0177), DRG 072 (Other Cerebrovascular Disorders without CC/MCC, relative weight 0.7348), DRG 974 (HIV with Major Related Condition with MCC, relative weight 3.0506), DRG 975 (HIV with Major Related Condition with CC, relative weight 1.3252) and DRG 976 (HIV with Major Related Condition without CC/MCC, relative weight 0.8124), in MDC 01 (Diseases and Disorders of the Nervous System) and MDC 25 (Human Immunodeficiency Virus Infections), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific leukoencephalopathy codes (official index)
- with
- brainstem - spinal cord involvement - lactate elevation E88.43 — Disorders of mitochondrial tRNA synthetases
- calcifications and cysts G93.43 — Leukoencephalopathy with calcifications and cysts
- thalamus - brainstem involvement - high lactate E88.43 — Disorders of mitochondrial tRNA synthetases
- adult-onset, with axonal spheroids (and pigmented glia) G93.44 — Adult-onset leukodystrophy with axonal spheroids
- Binswanger's I67.3 — Progressive vascular leukoencephalopathy
- heroin vapor G92.8 — Other toxic encephalopathy
- megalencephalic, with subcortical cysts G93.42 — Megalencephalic leukoencephalopathy with subcortical cysts
- metachromatic E75.25 — Metachromatic leukodystrophy
- multifocal (progressive) A81.2 — Progressive multifocal leukoencephalopathy
- postimmunization and postvaccinal G04.02 — Postimmunization acute disseminated encephalitis, myelitis and encephalomyelitis
- progressive multifocal A81.2 — Progressive multifocal leukoencephalopathy
- reversible, posterior G93.6 — Cerebral edema
- van Bogaert's (sclerosing) A81.1 — Subacute sclerosing panencephalitis
- vascular, progressive I67.3 — Progressive vascular leukoencephalopathy
Common questions about leukoencephalopathy ICD-10 codes
What is the ICD-10 code for leukoencephalopathy?
- G93.49 — Other encephalopathy. More specific codes apply when the documentation supports them: E88.43, G93.43, E88.43, G93.44 and others below.
What is the ICD-10 code for binswanger's leukoencephalopathy?
- I67.3 — Progressive vascular leukoencephalopathy.
What is the ICD-10 code for heroin vapor leukoencephalopathy?
- G92.8 — Other toxic encephalopathy.
What is the ICD-10 code for metachromatic leukoencephalopathy?
- E75.25 — Metachromatic leukodystrophy.
What is the ICD-10 code for multifocal leukoencephalopathy?
- A81.2 — Progressive multifocal leukoencephalopathy.
What is the ICD-10 code for postimmunization and postvaccinal leukoencephalopathy?
- G04.02 — Postimmunization acute disseminated encephalitis, myelitis and encephalomyelitis.
What is the ICD-10 code for progressive multifocal leukoencephalopathy?
- A81.2 — Progressive multifocal leukoencephalopathy.
Is G93.49 billable?
- Yes. G93.49 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can G93.49 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict G93.49 as a principal diagnosis.
Is G93.49 a CC or MCC?
- G93.49 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.