ICD-10-CM 2027
ICD-10 code for leukomalacia
From the official ICD-10-CM alphabetic index entry “Leukomalacia, cerebral, newborn”. Page updated September 29, 2026.
About coding leukomalacia
The ICD-10-CM code for leukomalacia is P91.2 (Neonatal cerebral leukomalacia). The official index lists 1 more specific code, so check the documentation for details such as type, cause, site or severity before settling on P91.2.
Within P91 (other disturbances of cerebral status of newborn), P91.2 is specifically for neonatal cerebral leukomalacia. Related codes cover neonatal cerebral ischemia (P91.0), acquired periventricular cysts of newborn (P91.1), neonatal cerebral irritability (P91.3), neonatal cerebral depression (P91.4), neonatal coma (P91.5), hypoxic ischemic encephalopathy [HIE] (P91.6), other specified disturbances of cerebral status of newborn (P91.8) and disturbance of cerebral status of newborn, unspecified (P91.9).
As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 091 (Other Disorders of Nervous System with MCC, relative weight 1.7046), DRG 092 (Other Disorders of Nervous System with CC, relative weight 1.0239), DRG 093 (Other Disorders of Nervous System without CC/MCC, relative weight 0.7783), DRG 791 (Prematurity with Major Problems, relative weight 4.1075) and DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), in MDC 01 (Diseases and Disorders of the Nervous System) and MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific leukomalacia codes (official index)
- periventricular P91.2 — Neonatal cerebral leukomalacia
Common questions about leukomalacia ICD-10 codes
What is the ICD-10 code for leukomalacia?
- P91.2 — Neonatal cerebral leukomalacia. More specific codes apply when the documentation supports them: P91.2.
What is the ICD-10 code for periventricular leukomalacia?
- P91.2 — Neonatal cerebral leukomalacia.
Is P91.2 billable?
- Yes. P91.2 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can P91.2 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict P91.2 as a principal diagnosis.
Is P91.2 a CC or MCC?
- P91.2 is an MCC (major complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.