ICD-10-CM 2027
ICD-10 code for Lymphoproliferation
Immunodeficiency following hereditary defective response to Epstein-Barr virus
From the official ICD-10-CM alphabetic index entry “Lymphoproliferation, X-linked disease”. Page updated September 29, 2026.
About coding Lymphoproliferation
The ICD-10-CM code for Lymphoproliferation is D82.3 (Immunodeficiency following hereditary defective response to Epstein-Barr virus).
Within D82 (immunodeficiency associated with other major defects), D82.3 is specifically for immunodeficiency following hereditary defective response to Epstein-Barr virus. Related codes cover Wiskott-Aldrich syndrome (D82.0), Di George's syndrome (D82.1), immunodeficiency with short-limbed stature (D82.2), Hyperimmunoglobulin E [IgE] syndrome (D82.4), immunodeficiency associated with other specified major defects (D82.8) and immunodeficiency associated with major defect, unspecified (D82.9).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 814 (Reticuloendothelial and Immunity Disorders with MCC, relative weight 2.0729), DRG 815 (Reticuloendothelial and Immunity Disorders with CC, relative weight 1.0444) and DRG 816 (Reticuloendothelial and Immunity Disorders without CC/MCC, relative weight 0.7381), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about Lymphoproliferation ICD-10 codes
What is the ICD-10 code for Lymphoproliferation?
- D82.3 — Immunodeficiency following hereditary defective response to Epstein-Barr virus.
Is D82.3 billable?
- Yes. D82.3 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D82.3 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D82.3 as a principal diagnosis.
Is D82.3 a CC or MCC?
- No. D82.3 is neither a CC nor an MCC under MS-DRG v44.0.