ICD-10-CM 2027
ICD-10 code for malignant neoplasm susceptibility to disease
From the official ICD-10-CM alphabetic index entry “Susceptibility to disease, genetic › malignant neoplasm”. Page updated September 29, 2026.
About coding malignant neoplasm susceptibility to disease
The ICD-10-CM code for malignant neoplasm susceptibility to disease is Z15.09 (Genetic susceptibility to other malignant neoplasm). The official index lists 6 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on Z15.09.
Within Z15.0, choose Z15.09 (other malignant neoplasm) only when documentation doesn't support a more specific option: of breast (Z15.01), of ovary (Z15.02), of prostate (Z15.03), of endometrium (Z15.04), of fallopian tube(s) (Z15.05), of digestive system (Z15.06) and of urinary tract (Z15.07).
Use an additional code, if applicable, for any associated family history of the disease (Z80-Z84).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
More specific malignant neoplasm susceptibility to disease codes (official index)
- breast Z15.01 — Genetic susceptibility to malignant neoplasm of breast
- endometrium Z15.04 — Genetic susceptibility to malignant neoplasm of endometrium
- fallopian tube (s) Z15.05 — Genetic susceptibility to malignant neoplasm of fallopian tube(s)
- ovary Z15.02 — Genetic susceptibility to malignant neoplasm of ovary
- prostate Z15.03 — Genetic susceptibility to malignant neoplasm of prostate
- specified NEC Z15.09 — Genetic susceptibility to other malignant neoplasm
Common questions about malignant neoplasm susceptibility to disease ICD-10 codes
What is the ICD-10 code for malignant neoplasm susceptibility to disease?
- Z15.09 — Genetic susceptibility to other malignant neoplasm. More specific codes apply when the documentation supports them: Z15.01, Z15.04, Z15.05, Z15.02 and others below.
What is the ICD-10 code for breast malignant neoplasm susceptibility to disease?
- Z15.01 — Genetic susceptibility to malignant neoplasm of breast.
What is the ICD-10 code for endometrium malignant neoplasm susceptibility to disease?
- Z15.04 — Genetic susceptibility to malignant neoplasm of endometrium.
What is the ICD-10 code for fallopian tube malignant neoplasm susceptibility to disease?
- Z15.05 — Genetic susceptibility to malignant neoplasm of fallopian tube(s).
What is the ICD-10 code for ovary malignant neoplasm susceptibility to disease?
- Z15.02 — Genetic susceptibility to malignant neoplasm of ovary.
What is the ICD-10 code for prostate malignant neoplasm susceptibility to disease?
- Z15.03 — Genetic susceptibility to malignant neoplasm of prostate.
Is Z15.09 billable?
- Yes. Z15.09 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can Z15.09 be used as a principal diagnosis?
- No. It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.
Is Z15.09 a CC or MCC?
- No. Z15.09 is neither a CC nor an MCC under MS-DRG v44.0.