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ICD-10-CM 2027 diagnosis code

Z15.06Genetic susceptibility to malignant neoplasm of digestive system

Not billable — use a more specific code

Z15.06 is a header code, so it can't be reported by itself. Choose one of the 2 more specific codes beneath it.Short description: Genetic susceptibility to malignant neoplasm of dgstv sys

Code last changed in FY2026 (effective October 1, 2025). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About Z15.06

Z15.06 is the ICD-10-CM diagnosis code for genetic susceptibility to malignant neoplasm of digestive system. It belongs to category Z15 (genetic susceptibility to disease), block Z14-Z15 (genetic carrier and genetic susceptibility to disease) and chapter 21 (factors influencing health status and contact with health services). It is a header code, so it can't be reported by itself; one of its 2 subcodes must be used instead.

Within Z15.0 (genetic susceptibility to malignant neoplasm), Z15.06 is specifically for genetic susceptibility to malignant neoplasm of digestive system. Related codes cover of breast (Z15.01), of ovary (Z15.02), of prostate (Z15.03), of endometrium (Z15.04), of fallopian tube(s) (Z15.05), of urinary tract (Z15.07) and other malignant neoplasm (Z15.09).

To report this condition, pick the subcode that matches the documentation: Z15.060 (cancer) and Z15.068 (system).

Use an additional code, if applicable, for any associated family history of the disease (Z80-Z84).

It was added in FY2026, effective October 1, 2025.

Specific codes under Z15.06

Notes that apply from higher levels

Instructions written at a parent level also apply to Z15.06.

› From Z15.0 Genetic susceptibility to malignant neoplasm
Code first
  • , if applicable, any current malignant neoplasm (C00-C75, C81-C96)
Use additional code
  • code, if applicable, for any personal history of malignant neoplasm (Z85.-)
› From Z15 Genetic susceptibility to disease
Includes
  • confirmed abnormal gene
Excludes1
  • chromosomal anomalies (Q90-Q99)
Use additional code
  • code, if applicable, for any associated family history of the disease (Z80-Z84)

Broader instructions also apply from Chapter 21: Factors influencing health status and contact with health services.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2026 (effective 10/1/2025): Added
  • No changes since FY2026.

Common questions about Z15.06

Is Z15.06 billable?

No. Z15.06 is a header code. Report one of its more specific subcodes instead.