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ICD-10-CM 2027 diagnosis code

Z15.0Genetic susceptibility to malignant neoplasm

Not billable — use a more specific code

Z15.0 is a header code, so it can't be reported by itself. Choose one of the 8 more specific codes beneath it.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About Z15.0

Z15.0 is the ICD-10-CM diagnosis code for genetic susceptibility to malignant neoplasm. It belongs to category Z15 (genetic susceptibility to disease), block Z14-Z15 (genetic carrier and genetic susceptibility to disease) and chapter 21 (factors influencing health status and contact with health services). It is a header code, so it can't be reported by itself; one of its 8 subcodes must be used instead.

Within Z15 (genetic susceptibility to disease), Z15.0 is specifically for genetic susceptibility to malignant neoplasm. Related codes cover epilepsy and neurodevelopmental disorders (Z15.1), obesity (Z15.2), kidney disease (Z15.3) and other disease (Z15.8).

To report this condition, pick the subcode that matches the documentation: Z15.01 (of breast), Z15.02 (of ovary), Z15.03 (of prostate), Z15.04 (of endometrium), Z15.05 (of fallopian tube(s)), Z15.06 (of digestive system), Z15.07 (of urinary tract) and Z15.09 (neoplasm).

Code first: , if applicable, any current malignant neoplasm (C00-C75, C81-C96).

Use an additional code, if applicable, for any personal history of malignant neoplasm (Z85.-). Use an additional code, if applicable, for any associated family history of the disease (Z80-Z84).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Specific codes under Z15.0

Coding notes

Code firstSequence the underlying condition first
  • , if applicable, any current malignant neoplasm (C00-C75, C81-C96)
Use additional codeAdd a secondary code to fully describe the condition
  • code, if applicable, for any personal history of malignant neoplasm (Z85.-)

Notes that apply from higher levels

Instructions written at a parent level also apply to Z15.0.

› From Z15 Genetic susceptibility to disease
Includes
  • confirmed abnormal gene
Excludes1
  • chromosomal anomalies (Q90-Q99)
Use additional code
  • code, if applicable, for any associated family history of the disease (Z80-Z84)

Broader instructions also apply from Chapter 21: Factors influencing health status and contact with health services.

Codes whose notes reference Z15.0

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about Z15.0

Is Z15.0 billable?

No. Z15.0 is a header code. Report one of its more specific subcodes instead.