ICD-10-CM 2027
ICD-10 code for multiple endocrine neoplasia susceptibility to disease
Genetic susceptibility to multiple endocrine neoplasia [MEN]
From the official ICD-10-CM alphabetic index entry “Susceptibility to disease, genetic › multiple endocrine neoplasia”. Page updated September 29, 2026.
About coding multiple endocrine neoplasia susceptibility to disease
The ICD-10-CM code for multiple endocrine neoplasia susceptibility to disease is Z15.81 (Genetic susceptibility to multiple endocrine neoplasia [MEN]).
Within Z15.8 (genetic susceptibility to other disease), Z15.81 is specifically for genetic susceptibility to multiple endocrine neoplasia [MEN]. Related codes cover other disease (Z15.89).
Don't report Z15.81 together with the conditions in its Excludes1 note: multiple endocrine neoplasia [MEN] syndromes (E31.2-).
Use an additional code, if applicable, for any associated family history of the disease (Z80-Z84).
Don't confuse with (Excludes1 for Z15.81)
- multiple endocrine neoplasia [MEN] syndromes (E31.2-)
Common questions about multiple endocrine neoplasia susceptibility to disease ICD-10 codes
What is the ICD-10 code for multiple endocrine neoplasia susceptibility to disease?
- Z15.81 — Genetic susceptibility to multiple endocrine neoplasia [MEN].
Is Z15.81 billable?
- Yes. Z15.81 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can Z15.81 be used as a principal diagnosis?
- No. It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.
Is Z15.81 a CC or MCC?
- No. Z15.81 is neither a CC nor an MCC under MS-DRG v44.0.