Z15.8Genetic susceptibility to other disease

Z15.8 is the ICD-10-CM diagnosis code for genetic susceptibility to other disease. It belongs to category Z15 (genetic susceptibility to disease), block Z14-Z15 (genetic carrier and genetic susceptibility to disease) and chapter 21 (factors influencing health status and contact with health services). It is a header code, so it can't be reported by itself; one of its 2 subcodes must be used instead.

Within Z15, choose Z15.8 (other disease) only when documentation doesn't support a more specific option: malignant neoplasm (Z15.0), epilepsy and neurodevelopmental disorders (Z15.1), obesity (Z15.2) and kidney disease (Z15.3).

To report this condition, pick the subcode that matches the documentation: Z15.81 ([MEN]) and Z15.89 (disease).

Use an additional code, if applicable, for any associated family history of the disease (Z80-Z84).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.