ICD-10-CM 2027
ICD-10 code for Prothrombin deficiency
Hereditary deficiency of other clotting factors
From the official ICD-10-CM alphabetic index entry “Deficiency, deficient › prothrombin (congenital) (heredItary)”. Page updated September 29, 2026.
About coding Prothrombin deficiency
The ICD-10-CM code for Prothrombin deficiency is D68.2 (Hereditary deficiency of other clotting factors). The official index lists 1 more specific code, so check the documentation for details such as type, cause, site or severity before settling on D68.2.
Within D68, choose D68.2 (Hereditary deficiency of other clotting factors) only when documentation doesn't support a more specific option: von Willebrand disease (D68.0), hereditary factor XI deficiency (D68.1), hemorrhagic disorder due to circulating anticoagulants (D68.3), acquired coagulation factor deficiency (D68.4), primary thrombophilia (D68.5), other thrombophilia (D68.6), other specified coagulation defects (D68.8) and coagulation defect, unspecified (D68.9).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 813 (Coagulation Disorders, relative weight 1.5257), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific Prothrombin deficiency codes (official index)
- acquired D68.4 — Acquired coagulation factor deficiency
Common questions about Prothrombin deficiency ICD-10 codes
What is the ICD-10 code for Prothrombin deficiency?
- D68.2 — Hereditary deficiency of other clotting factors. More specific codes apply when the documentation supports them: D68.4.
What is the ICD-10 code for acquired prothrombin deficiency?
- D68.4 — Acquired coagulation factor deficiency.
Is D68.2 billable?
- Yes. D68.2 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D68.2 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D68.2 as a principal diagnosis.
Is D68.2 a CC or MCC?
- D68.2 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.