ICD-10-CM 2027
ICD-10 code for secondary myelofibrosis
From the official ICD-10-CM alphabetic index entry “Myelofibrosis › secondary”. Page updated September 29, 2026.
About coding secondary myelofibrosis
The ICD-10-CM code for secondary myelofibrosis is D75.81 (Myelofibrosis). The official index lists 1 more specific code, so check the documentation for details such as type, cause, site or severity before settling on D75.81.
Within D75.8 (other specified diseases of blood and blood-forming organs), D75.81 is specifically for myelofibrosis. Related codes cover Heparin induced thrombocytopenia (HIT) (D75.82), thrombocytosis (D75.83), other platelet-activating anti-PF4 disorders (D75.84) and other specified diseases of blood and blood-forming organs (D75.89).
Don't report D75.81 together with the conditions in its Excludes1 note: acute myelofibrosis (C94.4-), idiopathic myelofibrosis (D47.1), leukoerythroblastic anemia (D61.82), myelofibrosis with myeloid metaplasia (D47.4) and 3 more.
Code first the underlying disorder, such as: malignant neoplasm of breast (C50.-).
More specific secondary myelofibrosis codes (official index)
- in myeloproliferative disease D47.4 — Osteomyelofibrosis
Don't confuse with (Excludes1 for D75.81)
Common questions about secondary myelofibrosis ICD-10 codes
What is the ICD-10 code for secondary myelofibrosis?
- D75.81 — Myelofibrosis. More specific codes apply when the documentation supports them: D47.4.
Is D75.81 billable?
- Yes. D75.81 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D75.81 be used as a principal diagnosis?
- No. It is a manifestation code, so it describes the effect of an underlying disease and can't be the principal diagnosis. Code the underlying condition first.
Is D75.81 a CC or MCC?
- D75.81 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.