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ICD-10-PCS 2027 procedure code

3E04002Introduction of High-dose Interleukin-2 into Central Vein, Open Approach

✓ Valid for 2027Non-O.R. procedure

Short description: Introduce of High dose IL-2 into Central Vein, Open Approach

Code unchanged since ICD-10-PCS took effect on October 1, 2015. Source: official FY2027 ICD-10-PCS release from CMS. Page updated September 29, 2026. About our data

About 3E04002

3E04002 is the ICD-10-PCS code for a introduction procedure on the central vein using an open approach with antineoplastic (qualifier: high-dose interleukin-2). In ICD-10-PCS, introduction means putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products.

In plain terms, this corresponds to High-dose infusion interleukin-2 [IL-2], the ICD-9-CM procedure title it maps to (00.15).

For a different body part, codes include 3E03002 (peripheral vein), 3E05002 (peripheral artery) and 3E06002 (central artery).

The same procedure with a different approach is coded 3E04302 (percutaneous).

It is a non-O.R. procedure that is part of the MS-DRG logic for DRG 837 (Chemotherapy with Acute Leukemia as Secondary Diagnosis or with High Dose Chemotherapy Agent with MCC) and DRG 838 (Chemotherapy with Acute Leukemia as Secondary Diagnosis with CC or High Dose Chemotherapy Agent), under the surgical category “Chemotherapy with Acute Leukemia As Secondary Diagnosis”.

It has been valid since ICD-10-PCS took effect on October 1, 2015.

What each character means

1. Section
3Administration
2. Body System
EPhysiological Systems and Anatomical Regions
3. Operation
0Introduction

Putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products

4. Body System / Region
4Central Vein
5. Approach
0Open

Cutting through the skin or mucous membrane and any other body layers necessary to expose the site of the procedure

6. Substance
0Antineoplastic

Includes: Amivantamab Monoclonal Antibody; Lurbinectedin; RYBREVANT (tm) (Amivantamab Monoclonal Antibody); ZEPZELCA(tm) (Lurbinectedin)

7. Qualifier
2High-dose Interleukin-2

Other versions of this procedure

Different approach

MS-DRG v44.0 grouping

All DRGs →

Surgical MS-DRGs this procedure can group to, depending on the principal diagnosis's MDC.

ICD-9-CM equivalent

Converter →
  • 00.15High-dose infusion interleukin-2 [IL-2]approximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about 3E04002

Is 3E04002 a valid ICD-10-PCS code for 2027?

Yes. 3E04002 is valid for inpatient procedures from October 1, 2026 through September 30, 2027.

Is 3E04002 an O.R. procedure?

No. 3E04002 is designated non-O.R. in MS-DRG v44.0.

What DRG does 3E04002 group to?

Depending on the principal diagnosis, 3E04002 can group to MS-DRG 837 and MS-DRG 838.

What is the ICD-9 procedure code for 3E04002?

The CMS GEMs map 3E04002 to ICD-9-CM 00.15 (High-dose infusion interleukin-2 [IL-2]).