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ICD-10-PCS 2027 procedure code

3E04003Introduction of Low-dose Interleukin-2 into Central Vein, Open Approach

✓ Valid for 2027

Short description: Introduce of Low dose IL-2 into Central Vein, Open Approach

Code unchanged since ICD-10-PCS took effect on October 1, 2015. Source: official FY2027 ICD-10-PCS release from CMS. Page updated September 29, 2026. About our data

About 3E04003

3E04003 is the ICD-10-PCS code for a introduction procedure on the central vein using an open approach with antineoplastic (qualifier: low-dose interleukin-2). In ICD-10-PCS, introduction means putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products.

In plain terms, this corresponds to injection or infusion of biological response modifier [BRM] as an antineoplastic agent, the ICD-9-CM procedure title it maps to (99.28).

For a different body part, codes include 3E03003 (peripheral vein), 3E05003 (peripheral artery) and 3E06003 (central artery).

The same procedure with a different approach is coded 3E04303 (percutaneous).

It doesn't appear in the MS-DRG procedure index, so on its own it doesn't change the DRG assignment.

It has been valid since ICD-10-PCS took effect on October 1, 2015.

What each character means

1. Section
3Administration
2. Body System
EPhysiological Systems and Anatomical Regions
3. Operation
0Introduction

Putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products

4. Body System / Region
4Central Vein
5. Approach
0Open

Cutting through the skin or mucous membrane and any other body layers necessary to expose the site of the procedure

6. Substance
0Antineoplastic

Includes: Amivantamab Monoclonal Antibody; Lurbinectedin; RYBREVANT (tm) (Amivantamab Monoclonal Antibody); ZEPZELCA(tm) (Lurbinectedin)

7. Qualifier
3Low-dose Interleukin-2

Other versions of this procedure

Different approach

ICD-9-CM equivalent

Converter →
  • 99.28Injection or infusion of biological response modifier [BRM] as an antineoplastic agentapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about 3E04003

Is 3E04003 a valid ICD-10-PCS code for 2027?

Yes. 3E04003 is valid for inpatient procedures from October 1, 2026 through September 30, 2027.

What is the ICD-9 procedure code for 3E04003?

The CMS GEMs map 3E04003 to ICD-9-CM 99.28 (Injection or infusion of biological response modifier [BRM] as an antineoplastic agent).