ICD-10-PCS 2027 procedure code
3E0400MIntroduction of Antineoplastic, Monoclonal Antibody, into Central Vein, Open Approach
Short description: Introduce Antneo, Moncln Ab, in Central Vein, Open
Code last changed in FY2022 (effective October 1, 2021). Source: official FY2027 ICD-10-PCS release from CMS. Page updated September 29, 2026. About our data
About 3E0400M
3E0400M is the ICD-10-PCS code for a introduction procedure on the central vein using an open approach with antineoplastic (qualifier: monoclonal antibody). In ICD-10-PCS, introduction means putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products.
In plain terms, this corresponds to injection or infusion of biological response modifier [BRM] as an antineoplastic agent, the ICD-9-CM procedure title it maps to (99.28).
For a different body part, codes include 3E0300M (peripheral vein), 3E0500M (peripheral artery), 3E0600M (central artery) and 3E0Q00M (cranial cavity and brain).
The same procedure with a different approach is coded 3E0430M (percutaneous).
It doesn't appear in the MS-DRG procedure index, so on its own it doesn't change the DRG assignment.
It has been valid since ICD-10-PCS took effect on October 1, 2015.
What each character means
- 1. Section
- 3Administration
- 2. Body System
- EPhysiological Systems and Anatomical Regions
- 3. Operation
- 0Introduction
Putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products
- 4. Body System / Region
- 4Central Vein
- 5. Approach
- 0Open
Cutting through the skin or mucous membrane and any other body layers necessary to expose the site of the procedure
- 6. Substance
- 0Antineoplastic
Includes: Amivantamab Monoclonal Antibody; Lurbinectedin; RYBREVANT (tm) (Amivantamab Monoclonal Antibody); ZEPZELCA(tm) (Lurbinectedin)
- 7. Qualifier
- MMonoclonal Antibody
Other versions of this procedure
Different body system / region
Different approach
ICD-9-CM equivalent
Converter →- 99.28Injection or infusion of biological response modifier [BRM] as an antineoplastic agentapproximate
From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- FY2022 (effective 10/1/2021): Title revised — was “Introduction of Monoclonal Antibody into Central Vein, Open Approach”
Common questions about 3E0400M
Is 3E0400M a valid ICD-10-PCS code for 2027?
- Yes. 3E0400M is valid for inpatient procedures from October 1, 2026 through September 30, 2027.
What is the ICD-9 procedure code for 3E0400M?
- The CMS GEMs map 3E0400M to ICD-9-CM 99.28 (Injection or infusion of biological response modifier [BRM] as an antineoplastic agent).