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ICD-10-PCS 2027 procedure code

3E0600MIntroduction of Antineoplastic, Monoclonal Antibody, into Central Artery, Open Approach

✓ Valid for 2027

Short description: Introduce Antneo, Moncln Ab, in Central Art, Open

Code last changed in FY2022 (effective October 1, 2021). Source: official FY2027 ICD-10-PCS release from CMS. Page updated September 29, 2026. About our data

About 3E0600M

3E0600M is the ICD-10-PCS code for a introduction procedure on the central artery using an open approach with antineoplastic (qualifier: monoclonal antibody). In ICD-10-PCS, introduction means putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products.

In plain terms, this corresponds to injection or infusion of biological response modifier [BRM] as an antineoplastic agent, the ICD-9-CM procedure title it maps to (99.28).

For a different body part, codes include 3E0300M (peripheral vein), 3E0400M (central vein), 3E0500M (peripheral artery) and 3E0Q00M (cranial cavity and brain).

The same procedure with a different approach is coded 3E0630M (percutaneous).

It doesn't appear in the MS-DRG procedure index, so on its own it doesn't change the DRG assignment.

It has been valid since ICD-10-PCS took effect on October 1, 2015.

What each character means

1. Section
3Administration
2. Body System
EPhysiological Systems and Anatomical Regions
3. Operation
0Introduction

Putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products

4. Body System / Region
6Central Artery
5. Approach
0Open

Cutting through the skin or mucous membrane and any other body layers necessary to expose the site of the procedure

6. Substance
0Antineoplastic

Includes: Amivantamab Monoclonal Antibody; Lurbinectedin; RYBREVANT (tm) (Amivantamab Monoclonal Antibody); ZEPZELCA(tm) (Lurbinectedin)

7. Qualifier
MMonoclonal Antibody

Other versions of this procedure

Different approach

ICD-9-CM equivalent

Converter →
  • 99.28Injection or infusion of biological response modifier [BRM] as an antineoplastic agentapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • FY2022 (effective 10/1/2021): Title revised — was “Introduction of Monoclonal Antibody into Central Artery, Open Approach”

Common questions about 3E0600M

Is 3E0600M a valid ICD-10-PCS code for 2027?

Yes. 3E0600M is valid for inpatient procedures from October 1, 2026 through September 30, 2027.

What is the ICD-9 procedure code for 3E0600M?

The CMS GEMs map 3E0600M to ICD-9-CM 99.28 (Injection or infusion of biological response modifier [BRM] as an antineoplastic agent).