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ICD-10-PCS 2027 procedure code

XW04368Introduction of Afamitresgene Autoleucel Immunotherapy into Central Vein, Percutaneous Approach, New Technology Group 8

✓ Valid for 2027Non-O.R. procedure

Short description: Introduce Afamitresgene in Central Vein, Perc, New Tech 8

Code last changed in FY2023 (effective October 1, 2022). Source: official FY2027 ICD-10-PCS release from CMS. Page updated September 29, 2026. About our data

About XW04368

XW04368 is the ICD-10-PCS code for a introduction procedure on the central vein using a percutaneous approach with afamitresgene autoleucel immunotherapy (qualifier: new technology group 8). In ICD-10-PCS, introduction means putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products.

For a different body part, codes include XW03368 (peripheral vein).

With a different device, use XW04308 (alpha1-proteinase inhibitor), XW04358 (ifezuntirgene inilparvovec), XW04378 (tabelecleucel immunotherapy), XW04388 (mineral-based topical hemostatic agent) and XW04398 (odronextamab antineoplastic).

It is a non-O.R. procedure that is part of the MS-DRG logic for DRG 018 (Chimeric Antigen Receptor (CAR) T-Cell and Other Immunotherapies), under the surgical category “Chimeric Antigen Receptor (CAR) T-Cell and Other Immunotherapies”.

It was added in FY2023, effective October 1, 2022.

What each character means

1. Section
XNew Technology
2. Body System
WAnatomical Regions
3. Operation
0Introduction

Putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products

4. Body Part
4Central Vein
5. Approach
3Percutaneous

Entry, by puncture or minor incision, of instrumentation through the skin or mucous membrane and any other body layers necessary to reach the site of the procedure

6. Device / Substance / Technology
6Afamitresgene Autoleucel Immunotherapy

Includes: afami-cel; TECELRA(R)

7. Qualifier
8New Technology Group 8

Other versions of this procedure

Different body part

MS-DRG v44.0 grouping

All DRGs →

Surgical MS-DRGs this procedure can group to, depending on the principal diagnosis's MDC.

MDC PRE · Pre-MDC · Chimeric Antigen Receptor (CAR) T-Cell and Other Immunotherapies

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2023 (effective 10/1/2022): Added
  • No changes since FY2023.

Common questions about XW04368

Is XW04368 a valid ICD-10-PCS code for 2027?

Yes. XW04368 is valid for inpatient procedures from October 1, 2026 through September 30, 2027.

Is XW04368 an O.R. procedure?

No. XW04368 is designated non-O.R. in MS-DRG v44.0.

What DRG does XW04368 group to?

Depending on the principal diagnosis, XW04368 can group to MS-DRG 018.