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ICD-10-CM 2027 diagnosis code

C48.0Malignant neoplasm of retroperitoneum

✓ Billable / specificCC — complication/comorbidity

C48.0 is a valid, billable ICD-10-CM code for malignant neoplasm of retroperitoneum. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About C48.0

C48.0 is the ICD-10-CM diagnosis code for malignant neoplasm of retroperitoneum. It belongs to category C48 (malignant neoplasm of retroperitoneum and peritoneum), block C45-C49 (malignant neoplasms of mesothelial and soft tissue) and chapter 2 (neoplasms). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within C48 (malignant neoplasm of retroperitoneum and peritoneum), C48.0 is specifically for malignant neoplasm of retroperitoneum. Related codes cover specified parts of peritoneum (C48.1), peritoneum, unspecified (C48.2) and overlapping sites of retroperitoneum and peritoneum (C48.8).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 826 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with MCC, relative weight 4.7581), DRG 827 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with CC, relative weight 2.3896), DRG 828 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures without CC/MCC, relative weight 1.6955), DRG 829 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures with CC/MCC, relative weight 3.1281), DRG 830 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures without CC/MCC, relative weight 1.4859), DRG 843 (Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses with MCC, relative weight 1.9453) and 2 more, in MDC 17 (Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 158.0 (malignant neoplasm of retroperitoneum).

Notes that apply from higher levels

Instructions written at a parent level also apply to C48.0.

› From C48 Malignant neoplasm of retroperitoneum and peritoneum
Excludes1
  • Kaposi's sarcoma of connective tissue (C46.1)
  • mesothelioma (C45.-)

Broader instructions also apply from Chapter 2: Neoplasms.

Table of Drugs & Neoplasms entries

Codes whose notes reference C48.0

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

ICD-9-CM equivalent

Converter →
  • 158.0Malignant neoplasm of retroperitoneumexact

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about C48.0

Is C48.0 billable?

Yes. C48.0 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can C48.0 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict C48.0 as a principal diagnosis.

Is C48.0 a CC or MCC?

C48.0 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.

What DRG does C48.0 group to?

C48.0 is used in the MS-DRG v44.0 logic for MS-DRG 826 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with MCC), MS-DRG 827 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with CC), MS-DRG 828 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures without CC/MCC), MS-DRG 829 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures with CC/MCC), MS-DRG 830 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures without CC/MCC), MS-DRG 843 (Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses with MCC) and 2 more. Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for C48.0?

The CMS General Equivalence Mappings map C48.0 to ICD-9-CM 158.0.