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ICD-10-CM 2027 diagnosis code

C83.390Primary central nervous system lymphoma

✓ Billable / specificCC — complication/comorbidity

C83.390 is a valid, billable ICD-10-CM code for primary central nervous system lymphoma. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Code last changed in FY2025 (effective October 1, 2024). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About C83.390

C83.390 is the ICD-10-CM diagnosis code for primary central nervous system lymphoma. It belongs to category C83 (non-follicular lymphoma), block C81-C96 (malignant neoplasms of lymphoid, hematopoietic and related tissue) and chapter 2 (neoplasms). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within C83.39 (diffuse large B-cell lymphoma, extranodal and solid organ sites), C83.390 is specifically for primary central nervous system lymphoma. Related codes cover diffuse large B-cell lymphoma of other extranodal and solid organ sites (C83.398).

Don't report C83.390 together with the conditions in its Excludes1 note: Primary central nervous system lymphoma, Burkitt (C83.79), Primary central nervous system lymphoma, lymphoblastic (C83.59), Primary central nervous system lymphoma, other (C83.89) and Primary central nervous system lymphoma, peripheral T-cell (C84.49).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 820 (Lymphoma and Leukemia with Major O.R. Procedures with MCC, relative weight 6.2481), DRG 821 (Lymphoma and Leukemia with Major O.R. Procedures with CC, relative weight 2.2023), DRG 822 (Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC, relative weight 1.1272), DRG 823 (Lymphoma and Non-Acute Leukemia with Other Procedures with MCC, relative weight 4.6059), DRG 824 (Lymphoma and Non-Acute Leukemia with Other Procedures with CC, relative weight 2.2515), DRG 825 (Lymphoma and Non-Acute Leukemia with Other Procedures without CC/MCC, relative weight 1.2995) and 6 more, in MDC 17 (Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms) and MDC 25 (Human Immunodeficiency Virus Infections), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It was added in FY2025, effective October 1, 2024.

Coding notes

Applicable toConditions and synonyms classified to this code
  • PCNSL of brain
  • PCNSL of meninges
  • PCNSL of spinal cord
  • PCNSL NOS
Excludes1Not coded here — never report together with this code
  • Primary central nervous system lymphoma, Burkitt (C83.79)
  • Primary central nervous system lymphoma, lymphoblastic (C83.59)
  • Primary central nervous system lymphoma, other (C83.89)
  • Primary central nervous system lymphoma, peripheral T-cell (C84.49)

Notes that apply from higher levels

Instructions written at a parent level also apply to C83.390.

› From C83.3 Diffuse large B-cell lymphoma
Excludes1
  • mediastinal (thymic) large B-cell lymphoma (C85.2-)
  • mature T/NK-cell lymphomas (C84.-)
› From C83 Non-follicular lymphoma
Excludes1
  • personal history of non-Hodgkin lymphoma (Z85.72)

Broader instructions also apply from C81-C96 Malignant neoplasms of lymphoid, hematopoietic and related tissue and Chapter 2: Neoplasms.

Alphabetic index entries

3 entries

Terms in the official ICD-10-CM index that lead to C83.390.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2025 (effective 10/1/2024): Added
  • No changes since FY2025.

Common questions about C83.390

Is C83.390 billable?

Yes. C83.390 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can C83.390 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict C83.390 as a principal diagnosis.

Is C83.390 a CC or MCC?

C83.390 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.

What DRG does C83.390 group to?

C83.390 is used in the MS-DRG v44.0 logic for MS-DRG 820 (Lymphoma and Leukemia with Major O.R. Procedures with MCC), MS-DRG 821 (Lymphoma and Leukemia with Major O.R. Procedures with CC), MS-DRG 822 (Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC), MS-DRG 823 (Lymphoma and Non-Acute Leukemia with Other Procedures with MCC), MS-DRG 824 (Lymphoma and Non-Acute Leukemia with Other Procedures with CC), MS-DRG 825 (Lymphoma and Non-Acute Leukemia with Other Procedures without CC/MCC) and 6 more. Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.