ICD-10-CM 2027 diagnosis code

D21.1Benign neoplasm of connective and other soft tissue of upper limb, including shoulder

Not billable — use a more specific code

D21.1 is a header code, so it can't be reported by itself. Choose one of the 3 more specific codes beneath it.Short description: Benign neoplm of connctv/soft tiss of upper limb, inc shldr

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About D21.1

D21.1 is the ICD-10-CM diagnosis code for benign neoplasm of connective and other soft tissue of upper limb, including shoulder. It belongs to category D21 (other benign neoplasms of connective and other soft tissue), block D10-D36 (benign neoplasms, except benign neuroendocrine tumors) and chapter 2 (neoplasms). It is a header code, so it can't be reported by itself; one of its 3 subcodes must be used instead.

Within D21 (other benign neoplasms of connective and other soft tissue), D21.1 is specifically for benign neoplasm of connective and other soft tissue of upper limb, including shoulder. Related codes cover tissue of head, face and neck (D21.0), tissue of lower limb, including hip (D21.2), tissue of thorax (D21.3), tissue of abdomen (D21.4), tissue of pelvis (D21.5), tissue of trunk, unspecified (D21.6) and tissue, unspecified (D21.9).

To report this condition, pick the subcode that matches the documentation: D21.10 (shoulder), D21.11 (shoulder) and D21.12 (shoulder).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Specific codes under D21.1

Notes that apply from higher levels

Instructions written at a parent level also apply to D21.1.

› From D21 Other benign neoplasms of connective and other soft tissue

Includes

benign neoplasm of blood vessel
benign neoplasm of bursa
benign neoplasm of cartilage
benign neoplasm of fascia
benign neoplasm of fat
benign neoplasm of ligament, except uterine
benign neoplasm of lymphatic channel
benign neoplasm of muscle
benign neoplasm of synovia
benign neoplasm of tendon (sheath)
benign stromal tumors

Excludes1

benign neoplasm of articular cartilage (D16.-)
benign neoplasm of cartilage of larynx (D14.1)
benign neoplasm of cartilage of nose (D14.0)
benign neoplasm of connective tissue of breast (D24.-)
benign neoplasm of peripheral nerves and autonomic nervous system (D36.1-)
benign neoplasm of peritoneum (D20.1)
benign neoplasm of retroperitoneum (D20.0)
benign neoplasm of uterine ligament, any (D28.2)
benign neoplasm of vascular tissue (D18.-)
hemangioma (D18.0-)
lipomatous neoplasm (D17.-)
lymphangioma (D18.1)
uterine leiomyoma (D25.-)

Broader instructions also apply from Chapter 2: Neoplasms.

Table of Drugs & Neoplasms entries

Neoplasm, neoplastic › aponeurosis › palmar — Benign
Neoplasm, neoplastic › connective tissue NEC › antecubital fossa or space — Benign
Neoplasm, neoplastic › connective tissue NEC › arm — Benign
Neoplasm, neoplastic › connective tissue NEC › elbow — Benign
Neoplasm, neoplastic › connective tissue NEC › extremity › upper — Benign
Neoplasm, neoplastic › connective tissue NEC › finger — Benign
Neoplasm, neoplastic › connective tissue NEC › forearm — Benign
Neoplasm, neoplastic › connective tissue NEC › hand — Benign
Neoplasm, neoplastic › connective tissue NEC › limb NEC › upper — Benign
Neoplasm, neoplastic › connective tissue NEC › shoulder — Benign
Neoplasm, neoplastic › connective tissue NEC › thumb — Benign
Neoplasm, neoplastic › connective tissue NEC › wrist — Benign
Neoplasm, neoplastic › fascia › palmar — Benign

Code history

2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
2027

FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
No changes since FY2016.

Common questions about D21.1

Is D21.1 billable?: No. D21.1 is a header code. Report one of its more specific subcodes instead.