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ICD-10-CM 2027 diagnosis code

D21.6Benign neoplasm of connective and other soft tissue of trunk, unspecified

✓ Billable / specific

D21.6 is a valid, billable ICD-10-CM code for benign neoplasm of connective and other soft tissue of trunk, unspecified. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Benign neoplasm of connctv/soft tiss of trunk, unsp

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About D21.6

D21.6 is the ICD-10-CM diagnosis code for benign neoplasm of connective and other soft tissue of trunk, unspecified. It belongs to category D21 (other benign neoplasms of connective and other soft tissue), block D10-D36 (benign neoplasms, except benign neuroendocrine tumors) and chapter 2 (neoplasms). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within D21, choose D21.6 (tissue of trunk, unspecified) only when documentation doesn't support a more specific option: tissue of head, face and neck (D21.0), tissue of upper limb, including shoulder (D21.1), tissue of lower limb, including hip (D21.2), tissue of thorax (D21.3), tissue of abdomen (D21.4), tissue of pelvis (D21.5) and tissue, unspecified (D21.9).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 564 (Other Musculoskeletal System and Connective Tissue Diagnoses with MCC, relative weight 1.4908), DRG 565 (Other Musculoskeletal System and Connective Tissue Diagnoses with CC, relative weight 0.9783) and DRG 566 (Other Musculoskeletal System and Connective Tissue Diagnoses without CC/MCC, relative weight 0.7378), in MDC 08 (Diseases and Disorders of the Musculoskeletal System and Connective Tissue), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 215.7 (other benign neoplasm of connective and other soft tissue of trunk, unspecified).

Coding notes

Applicable toConditions and synonyms classified to this code
  • Benign neoplasm of connective and other soft tissue of back NOS

Notes that apply from higher levels

Instructions written at a parent level also apply to D21.6.

› From D21 Other benign neoplasms of connective and other soft tissue
Includes
  • benign neoplasm of blood vessel
  • benign neoplasm of bursa
  • benign neoplasm of cartilage
  • benign neoplasm of fascia
  • benign neoplasm of fat
  • benign neoplasm of ligament, except uterine
  • benign neoplasm of lymphatic channel
  • benign neoplasm of muscle
  • benign neoplasm of synovia
  • benign neoplasm of tendon (sheath)
  • benign stromal tumors
Excludes1
  • benign neoplasm of articular cartilage (D16.-)
  • benign neoplasm of cartilage of larynx (D14.1)
  • benign neoplasm of cartilage of nose (D14.0)
  • benign neoplasm of connective tissue of breast (D24.-)
  • benign neoplasm of peripheral nerves and autonomic nervous system (D36.1-)
  • benign neoplasm of peritoneum (D20.1)
  • benign neoplasm of retroperitoneum (D20.0)
  • benign neoplasm of uterine ligament, any (D28.2)
  • benign neoplasm of vascular tissue (D18.-)
  • hemangioma (D18.0-)
  • lipomatous neoplasm (D17.-)
  • lymphangioma (D18.1)
  • uterine leiomyoma (D25.-)

Broader instructions also apply from Chapter 2: Neoplasms.

Table of Drugs & Neoplasms entries

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

ICD-9-CM equivalent

Converter →
  • 215.7Other benign neoplasm of connective and other soft tissue of trunk, unspecifiedexact

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about D21.6

Is D21.6 billable?

Yes. D21.6 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can D21.6 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict D21.6 as a principal diagnosis.

Is D21.6 a CC or MCC?

No. D21.6 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does D21.6 group to?

D21.6 is used in the MS-DRG v44.0 logic for MS-DRG 564 (Other Musculoskeletal System and Connective Tissue Diagnoses with MCC), MS-DRG 565 (Other Musculoskeletal System and Connective Tissue Diagnoses with CC) and MS-DRG 566 (Other Musculoskeletal System and Connective Tissue Diagnoses without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for D21.6?

The CMS General Equivalence Mappings map D21.6 to ICD-9-CM 215.7.