ICD-10-CM 2027 diagnosis code
D49.9Neoplasm of unspecified behavior of unspecified site
D49.9 is a valid, billable ICD-10-CM code for neoplasm of unspecified behavior of unspecified site. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About D49.9
D49.9 is the ICD-10-CM diagnosis code for neoplasm of unspecified behavior of unspecified site. It belongs to category D49 (neoplasms of unspecified behavior), block D49 (neoplasms of unspecified behavior) and chapter 2 (neoplasms). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within D49, choose D49.9 (unspecified site) only when documentation doesn't support a more specific option: digestive system (D49.0), respiratory system (D49.1), bone, soft tissue, and skin (D49.2), breast (D49.3), bladder (D49.4), other genitourinary organs (D49.5), brain (D49.6), endocrine glands and other parts of nervous system (D49.7) and 1 more.
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 826 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with MCC, relative weight 4.7581), DRG 827 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with CC, relative weight 2.3896), DRG 828 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures without CC/MCC, relative weight 1.6955), DRG 829 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures with CC/MCC, relative weight 3.1281), DRG 830 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures without CC/MCC, relative weight 1.4859), DRG 843 (Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses with MCC, relative weight 1.9453) and 2 more, in MDC 17 (Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Before ICD-10, this condition was coded in ICD-9-CM as 239.9 (neoplasm of unspecified nature, site unspecified).
Notes that apply from higher levels
Instructions written at a parent level also apply to D49.9.
Broader instructions also apply from Chapter 2: Neoplasms.
Alphabetic index entries
15 entriesTerms in the official ICD-10-CM index that lead to D49.9.
- Arthropathy › in (due to) › neoplastic disease NOS (see also Neoplasm)
- Ataxia, ataxy, ataxic › cerebellar (hereditary) › in › neoplastic disease
- Atrophy, atrophic (of) › systemic affecting central nervous system › in › neoplastic disease
- Compression › nerve › root or plexus NOS (in) › neoplastic disease
- Dermatomyositis (acute) (chronic) › in (due to) neoplastic disease
- Dermatopolymyositis › in neoplastic disease
- Encephalopathy (acute) › in (due to) (with) › neoplastic disease (see also Neoplasm)
- Myasthenia › syndrome › in › neoplastic disease
- Myelopathy (spinal cord) › in (due to) › neoplastic disease
- Neuromyopathy › paraneoplastic (see also, Neoplasm, by site, if known)
- Neuropathy, neuropathic › paraneoplastic (sensorial) (Denny Brown) (see also, Neoplasm, by site, if known)
- Osteitis › deformans › in (due to) › neoplastic disease
- Palsy › cranial nerve › multiple › in › neoplastic disease
- Polyneuropathy (peripheral) › in (due to) › neoplastic disease
- Syndrome › myasthenic › in › neoplastic disease
Table of Drugs & Neoplasms entries
- Neoplasm, neoplastic — Unspecified Behavior
- Neoplasm, neoplastic › unknown site or unspecified — Unspecified Behavior
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 17 · Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms
- 826Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with MCCRW 4.7581
- 827Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with CCRW 2.3896
- 828Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures without CC/MCCRW 1.6955
MDC 17 · Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms
MDC 17 · Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms
- 843Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses with MCCRW 1.9453
- 844Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses with CCRW 1.2551
- 845Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses without CC/MCCRW 0.8447
ICD-9-CM equivalent
Converter →- 239.9Neoplasm of unspecified nature, site unspecifiedexact
From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about D49.9
Is D49.9 billable?
- Yes. D49.9 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D49.9 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D49.9 as a principal diagnosis.
Is D49.9 a CC or MCC?
- No. D49.9 is neither a CC nor an MCC under MS-DRG v44.0.
What DRG does D49.9 group to?
- D49.9 is used in the MS-DRG v44.0 logic for MS-DRG 826 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with MCC), MS-DRG 827 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with CC), MS-DRG 828 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures without CC/MCC), MS-DRG 829 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures with CC/MCC), MS-DRG 830 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures without CC/MCC), MS-DRG 843 (Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses with MCC) and 2 more. Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.
What is the ICD-9 code for D49.9?
- The CMS General Equivalence Mappings map D49.9 to ICD-9-CM 239.9.