ICD-10-CM 2027 diagnosis code
D59.12Cold autoimmune hemolytic anemia
D59.12 is a valid, billable ICD-10-CM code for cold autoimmune hemolytic anemia. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.
Code last changed in FY2021 (effective October 1, 2020). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About D59.12
D59.12 is the ICD-10-CM diagnosis code for cold autoimmune hemolytic anemia. It belongs to category D59 (acquired hemolytic anemia), block D55-D59 (hemolytic anemias) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within D59.1 (other autoimmune hemolytic anemias), D59.12 is specifically for cold autoimmune hemolytic anemia. Related codes cover autoimmune hemolytic anemia, unspecified (D59.10), Warm autoimmune hemolytic anemia (D59.11), mixed type autoimmune hemolytic anemia (D59.13) and other autoimmune hemolytic anemia (D59.19).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 808 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC, relative weight 2.1705), DRG 809 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC, relative weight 1.2262) and DRG 810 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC, relative weight 1.075), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It was added in FY2021, effective October 1, 2020.
Coding notes
- Chronic cold hemagglutinin disease
- Cold agglutinin disease
- Cold agglutinin hemoglobinuria
- Cold type (primary) (secondary) (symptomatic) autoimmune hemolytic anemia
- Cold type autoimmune hemolytic disease
Notes that apply from higher levels
Instructions written at a parent level also apply to D59.12.
Broader instructions also apply from Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism.
Alphabetic index entries
13 entriesTerms in the official ICD-10-CM index that lead to D59.12.
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › autoimmune › cold
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › cold type (primary) (secondary) (symptomatic)
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › primary › autoimmune › cold type
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › secondary › autoimmune › cold type
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › hemolytic › symptomatic › autoimmune › cold type
- Cold › agglutinin disease or hemoglobinuria (chronic)
- Cold › sensitivity, auto-immune
- Disease, diseased › autoimmune (systemic) NOS › hemolytic › cold type (primary) (secondary) (symptomatic)
- Disease, diseased › cold › agglutinin or hemoglobinuria
- Disease, diseased › cold › hemagglutinin (chronic)
- Disease, diseased › hemolytic (newborn) › autoimmune › cold type (primary) (secondary) (symptomatic)
- Hemoglobinuria › cold (paroxysmal) (with Raynaud's syndrome) › agglutinin
- Sensitive, sensitivity › cold, autoimmune
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 16 · Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders
- 808Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCCRW 2.1705
- 809Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CCRW 1.2262
- 810Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCCRW 1.075
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2021 (effective 10/1/2020): Added
- No changes since FY2021.
Common questions about D59.12
Is D59.12 billable?
- Yes. D59.12 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D59.12 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D59.12 as a principal diagnosis.
Is D59.12 a CC or MCC?
- D59.12 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.
What DRG does D59.12 group to?
- D59.12 is used in the MS-DRG v44.0 logic for MS-DRG 808 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC), MS-DRG 809 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC) and MS-DRG 810 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.