D59.6Hemoglobinuria due to hemolysis from other external causes

D59.6 is the ICD-10-CM diagnosis code for hemoglobinuria due to hemolysis from other external causes. It belongs to category D59 (acquired hemolytic anemia), block D55-D59 (hemolytic anemias) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within D59, choose D59.6 (Hemoglobinuria due to hemolysis from other external causes) only when documentation doesn't support a more specific option: drug-induced autoimmune hemolytic anemia (D59.0), other autoimmune hemolytic anemias (D59.1), drug-induced nonautoimmune hemolytic anemia (D59.2), hemolytic-uremic syndrome (D59.3), other nonautoimmune hemolytic anemias (D59.4), paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] (D59.5), other acquired hemolytic anemias (D59.8) and unspecified (D59.9).

Don't report D59.6 together with the conditions in its Excludes1 note: hemoglobinuria NOS (R82.3).

Use an additional code (Chapter 20) to identify external cause.

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 791 (Prematurity with Major Problems, relative weight 4.1075), DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), DRG 808 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC, relative weight 2.1705), DRG 809 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC, relative weight 1.2262) and DRG 810 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC, relative weight 1.075), in MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period) and MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 283.2 (hemoglobinuria due to hemolysis from external causes).