ICD-10-CM 2027 diagnosis code
E22Hyperfunction of pituitary gland
E22 is a header code, so it can't be reported by itself. Choose one of the 5 more specific codes beneath it.
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About E22
E22 is the ICD-10-CM diagnosis code for hyperfunction of pituitary gland. It belongs to block E20-E35 (disorders of other endocrine glands) and chapter 4 (endocrine, nutritional and metabolic diseases). It is a header code, so it can't be reported by itself; one of its 5 subcodes must be used instead.
To report this condition, pick the subcode that matches the documentation: E22.0 (gigantism), E22.1 (Hyperprolactinemia), E22.2 (hormone), E22.8 (gland) and E22.9 (unspecified).
Don't report E22 together with the conditions in its Excludes1 note: Cushing's syndrome (E24.-), Nelson's syndrome (E24.1), overproduction of ACTH not associated with Cushing's disease (E27.0), overproduction of pituitary ACTH (E24.0) and 1 more.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Specific codes under E22
Coding notes
Notes that apply from higher levels
Instructions written at a parent level also apply to E22.
Broader instructions also apply from E20-E35 Disorders of other endocrine glands and Chapter 4: Endocrine, nutritional and metabolic diseases.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about E22
Is E22 billable?
- No. E22 is a header code. Report one of its more specific subcodes instead.