ICD-10-CM 2027 diagnosis code
E22.0Acromegaly and pituitary gigantism
E22.0 is a valid, billable ICD-10-CM code for acromegaly and pituitary gigantism. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.
Looking up by condition? See ICD-10 code for Gigantism, ICD-10 code for Acromegaly, ICD-10 code for Macrospondylitis, ICD-10 code for Launois' syndrome.
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About E22.0
E22.0 is the ICD-10-CM diagnosis code for Acromegaly and pituitary gigantism. It belongs to category E22 (hyperfunction of pituitary gland), block E20-E35 (disorders of other endocrine glands) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within E22 (hyperfunction of pituitary gland), E22.0 is specifically for Acromegaly and pituitary gigantism. Related codes cover Hyperprolactinemia (E22.1), syndrome of inappropriate secretion of antidiuretic hormone (E22.2), other hyperfunction of pituitary gland (E22.8) and unspecified (E22.9).
Don't report E22.0 together with the conditions in its Excludes1 note: constitutional gigantism (E34.4), constitutional tall stature (E34.4) and increased secretion from endocrine pancreas of growth hormone-releasing hormone (E16.8).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Before ICD-10, this condition was coded in ICD-9-CM as 253.0 (Acromegaly and gigantism).
Coding notes
- Overproduction of growth hormone
Notes that apply from higher levels
Instructions written at a parent level also apply to E22.0.
Broader instructions also apply from E20-E35 Disorders of other endocrine glands and Chapter 4: Endocrine, nutritional and metabolic diseases.
Alphabetic index entries
20 entriesTerms in the official ICD-10-CM index that lead to E22.0.
- Acromegaly, acromegalia
- Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute) › due to or associated with › acromegaly
- Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute) › in (due to) › acromegaly
- Arthropathy › in (due to) › acromegaly
- Erdheim's syndrome (acromegalic macrospondylitis)
- Gigantism (cerebral) (hypophyseal) (pituitary)
- Hypersecretion › hormone (s) › growth
- Hypophyseal, hypophysis › gigantism
- Launois' syndrome (pituitary gigantism)
- Macrospondylitis , acromegalic
- Marie's › disease or syndrome (acromegaly)
- Overproduction › growth hormone
- Scaglietti-Dagnini syndrome
- Syndrome › cerebral › gigantism
- Syndrome › costovertebral
- Syndrome › Erdheim's
- Syndrome › Launois'
- Syndrome › Marie's (acromegaly)
- Syndrome › pituitary
- Syndrome › Scaglietti-Dagnini
Codes whose notes reference E22.0
- M26.0Excludes1
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 10 · Endocrine, Nutritional and Metabolic Diseases and Disorders
ICD-9-CM equivalent
Converter →- 253.0Acromegaly and gigantismapproximate
From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about E22.0
Is E22.0 billable?
- Yes. E22.0 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E22.0 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E22.0 as a principal diagnosis.
Is E22.0 a CC or MCC?
- No. E22.0 is neither a CC nor an MCC under MS-DRG v44.0.
What DRG does E22.0 group to?
- E22.0 is used in the MS-DRG v44.0 logic for MS-DRG 643 (Endocrine Disorders with MCC), MS-DRG 644 (Endocrine Disorders with CC) and MS-DRG 645 (Endocrine Disorders without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.
What is the ICD-9 code for E22.0?
- The CMS General Equivalence Mappings map E22.0 to ICD-9-CM 253.0.