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ICD-10-CM 2027 diagnosis code

M31.11Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]

✓ Billable / specificMCC — major complication/comorbidity

M31.11 is a valid, billable ICD-10-CM code for hematopoietic stem cell transplantation-associated thrombotic microangiopathy [hsct-tma]. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Hematpoetc stem cell txpltation-assoc throm microangiopathy

Looking up by condition? See ICD-10 code for HSCT-TMA.

Code last changed in FY2022 (effective October 1, 2021). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About M31.11

M31.11 is the ICD-10-CM diagnosis code for hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]. It belongs to category M31 (other necrotizing vasculopathies), block M30-M36 (systemic connective tissue disorders) and chapter 13 (diseases of the musculoskeletal system and connective tissue). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within M31.1 (thrombotic microangiopathy), M31.11 is specifically for hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]. Related codes cover unspecified (M31.10) and other thrombotic microangiopathy (M31.19).

Code first if applicable: complications of bone marrow transplant (T86.0-) and complications of stem cell transplant (T86.5).

Use an additional code to identify specific organ dysfunction, such as: acute kidney failure (N17.-), acute respiratory distress syndrome (J80), capillary leak syndrome (I78.8), diffuse alveolar hemorrhage (R04.89), encephalopathy (metabolic) (septic) (G93.41) and 7 more.

As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 545 (Connective Tissue Disorders with MCC, relative weight 2.3892), DRG 546 (Connective Tissue Disorders with CC, relative weight 1.1745) and DRG 547 (Connective Tissue Disorders without CC/MCC, relative weight 0.7526), in MDC 08 (Diseases and Disorders of the Musculoskeletal System and Connective Tissue), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It was added in FY2022, effective October 1, 2021.

Coding notes

Applicable toConditions and synonyms classified to this code
  • Transplant-associated thrombotic microangiopathy [TA-TMA]
Code firstSequence the underlying condition first
  • if applicable:
  • complications of bone marrow transplant (T86.0-)
  • complications of stem cell transplant (T86.5)
Use additional codeAdd a secondary code to fully describe the condition
  • code to identify specific organ dysfunction, such as:
  • acute kidney failure (N17.-)
  • acute respiratory distress syndrome (J80)
  • capillary leak syndrome (I78.8)
  • diffuse alveolar hemorrhage (R04.89)
  • encephalopathy (metabolic) (septic) (G93.41)
  • fluid overload, unspecified (E87.70)
  • graft versus host disease (D89.81-)
  • hemolytic uremic syndrome (D59.3-)
  • hepatic failure (K72.-)
  • hepatic veno-occlusive disease (K76.5)
  • idiopathic interstitial pneumonia (J84.11-)
  • sinusoidal obstruction syndrome (K76.5)

Notes that apply from higher levels

Instructions written at a parent level also apply to M31.11.

Broader instructions also apply from M30-M36 Systemic connective tissue disorders and Chapter 13: Diseases of the musculoskeletal system and connective tissue.

Alphabetic index entries

2 entries

Terms in the official ICD-10-CM index that lead to M31.11.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2022 (effective 10/1/2021): Added
  • No changes since FY2022.

Common questions about M31.11

Is M31.11 billable?

Yes. M31.11 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can M31.11 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict M31.11 as a principal diagnosis.

Is M31.11 a CC or MCC?

M31.11 is an MCC (major complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.

What DRG does M31.11 group to?

M31.11 is used in the MS-DRG v44.0 logic for MS-DRG 545 (Connective Tissue Disorders with MCC), MS-DRG 546 (Connective Tissue Disorders with CC) and MS-DRG 547 (Connective Tissue Disorders without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.