D89.81Graft-versus-host disease

D89.81 is the ICD-10-CM diagnosis code for graft-versus-host disease. It belongs to category D89 (other disorders involving the immune mechanism, not elsewhere classified), block D80-D89 (certain disorders involving the immune mechanism) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is a header code, so it can't be reported by itself; one of its 4 subcodes must be used instead.

Within D89.8 (other specified disorders involving the immune mechanism, not elsewhere classified), D89.81 is specifically for graft-versus-host disease. Related codes cover autoimmune lymphoproliferative syndrome [ALPS] (D89.82), Cytokine release syndrome (D89.83), IgG4-related disease (D89.84) and other specified disorders involving the immune mechanism, not elsewhere classified (D89.89).

To report this condition, pick the subcode that matches the documentation: D89.810 (disease), D89.811 (disease), D89.812 (disease) and D89.813 (unspecified).

Code first underlying cause, such as: complications of transplanted organs and tissue (T86.-) and complications of blood transfusion (T80.89).

Use an additional code to identify associated manifestations, such as: desquamative dermatitis (L30.8), diarrhea (R19.7), elevated bilirubin (R17) and hair loss (L65.9).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.