R65.1Systemic inflammatory response syndrome (SIRS) of non-infectious origin

R65.1 is the ICD-10-CM diagnosis code for systemic inflammatory response syndrome (SIRS) of non-infectious origin. It belongs to category R65 (symptoms and signs specifically associated with systemic inflammation and infection), block R50-R69 (general symptoms and signs) and chapter 18 (symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified). It is a header code, so it can't be reported by itself; one of its 2 subcodes must be used instead.

Within R65 (symptoms and signs specifically associated with systemic inflammation and infection), R65.1 is specifically for systemic inflammatory response syndrome (SIRS) of non-infectious origin. Related codes cover severe sepsis (R65.2).

To report this condition, pick the subcode that matches the documentation: R65.10 (without acute organ dysfunction) and R65.11 (with acute organ dysfunction).

Don't report R65.1 together with the conditions in its Excludes1 note: sepsis- code to infection and severe sepsis (R65.2).

Code first underlying condition, such as: heatstroke (T67.0-) and injury and trauma (S00-T88).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.