R65.11Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

R65.11 is the ICD-10-CM diagnosis code for systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction. It belongs to category R65 (symptoms and signs specifically associated with systemic inflammation and infection), block R50-R69 (general symptoms and signs) and chapter 18 (symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within R65.1 (systemic inflammatory response syndrome (SIRS) of non-infectious origin), R65.11 is specifically for systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction. Related codes cover without acute organ dysfunction (R65.10).

Use an additional code to identify specific acute organ dysfunction, such as: acute kidney failure (N17.-), acute respiratory failure (J96.0-), critical illness myopathy (G72.81), critical illness polyneuropathy (G62.81), disseminated intravascular coagulopathy [DIC] (D65) and 2 more.

As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 864 (Fever and Inflammatory Conditions, relative weight 0.8551), in MDC 18 (Infectious and Parasitic Diseases, Systemic or Unspecified Sites), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 995.94 (systemic inflammatory response syndrome due to noninfectious process with acute organ dysfunction).