R65.10Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction

R65.10 is the ICD-10-CM diagnosis code for systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction. It belongs to category R65 (symptoms and signs specifically associated with systemic inflammation and infection), block R50-R69 (general symptoms and signs) and chapter 18 (symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within R65.1, choose R65.10 (without acute organ dysfunction) only when documentation doesn't support a more specific option: with acute organ dysfunction (R65.11).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 864 (Fever and Inflammatory Conditions, relative weight 0.8551), in MDC 18 (Infectious and Parasitic Diseases, Systemic or Unspecified Sites), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 995.93 (systemic inflammatory response syndrome due to noninfectious process without acute organ dysfunction).