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ICD-10-CM 2027 diagnosis code

T45.8X5SAdverse effect of other primarily systemic and hematological agents, sequela

✓ Billable / specificPOA exemptRequires 7th characterNot a principal dx

T45.8X5S is a valid, billable ICD-10-CM code for adverse effect of other primarily systemic and hematological agents, sequela. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Adverse effect of prim sys and hematolog agents, sequela

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About T45.8X5S

T45.8X5S is the ICD-10-CM diagnosis code for adverse effect of other primarily systemic and hematological agents, sequela. It belongs to category T45 (poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified), block T36-T50 (poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances) and chapter 19 (injury, poisoning and certain other consequences of external causes). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

The 7th character "S" means sequela: use it for complications or conditions that arise as a direct result of the original condition.

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 922 (Other Injury, Poisoning and Toxic Effect Diagnoses with MCC, relative weight 1.6238) and DRG 923 (Other Injury, Poisoning and Toxic Effect Diagnoses without MCC, relative weight 0.9973), in MDC 21 (Injuries, Poisonings and Toxic Effects of Drugs), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.

It is exempt from present-on-admission (POA) reporting, so no POA indicator is required.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 909.5 (late effect of adverse effect of drug, medicinal or biological substance), 909.5 (late effect of adverse effect of drug, medicinal or biological substance), E933.6 (oral bisphosphonates) and 3 more.

7th character

Ssequela

Other encounter types for T45.8X5:

Notes that apply from higher levels

Instructions written at a parent level also apply to T45.8X5S.

› From T45.8 Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents
Excludes2
  • poisoning by, adverse effect of and underdosing of immunoglobulin (T50.Z1)
  • poisoning by, adverse effect of and underdosing of iron (T45.4)
  • transfusion reactions (T80.-)

Broader instructions also apply from T36-T50 Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances and Chapter 19: Injury, poisoning and certain other consequences of external causes.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

ICD-9-CM equivalent

Converter →
  • 909.5Late effect of adverse effect of drug, medicinal or biological substanceapproximate, combination
  • 909.5Late effect of adverse effect of drug, medicinal or biological substanceapproximate, combination
  • E933.6Oral bisphosphonatesapproximate, combination
  • E933.7Intravenous bisphosphonatesapproximate, combination
  • E933.8Other systemic agents, not elsewhere classified, causing adverse effects in therapeutic useapproximate, combination
  • E934.8Other agents affecting blood constituents causing adverse effects in therapeutic useapproximate, combination

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about T45.8X5S

Is T45.8X5S billable?

Yes. T45.8X5S is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

What does the "S" at the end of T45.8X5S mean?

It is the 7th character for sequela. Per the official guidelines, use it for complications or conditions that arise as a direct result of the original condition.

Can T45.8X5S be used as a principal diagnosis?

No. It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.

Is T45.8X5S a CC or MCC?

No. T45.8X5S is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does T45.8X5S group to?

T45.8X5S is used in the MS-DRG v44.0 logic for MS-DRG 922 (Other Injury, Poisoning and Toxic Effect Diagnoses with MCC) and MS-DRG 923 (Other Injury, Poisoning and Toxic Effect Diagnoses without MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for T45.8X5S?

The CMS General Equivalence Mappings map T45.8X5S to ICD-9-CM 909.5, 909.5, E933.6, E933.7 and 2 more.