ICD-10-CM 2027 diagnosis code
T45.8X5Adverse effect of other primarily systemic and hematological agents
T45.8X5 is a header code, so it can't be reported by itself. Choose one of the 3 more specific codes beneath it and add the required 7th character.Short description: Adverse effect of primarily systemic and hematolog agents
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About T45.8X5
T45.8X5 is the ICD-10-CM diagnosis code for adverse effect of other primarily systemic and hematological agents. It belongs to category T45 (poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified), block T36-T50 (poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances) and chapter 19 (injury, poisoning and certain other consequences of external causes). It is a header code, so it can't be reported by itself; one of its 3 subcodes must be used instead.
Within T45.8X, choose T45.8X5 (Adverse effect of other primarily systemic and hematological agents) only when documentation doesn't support a more specific option: poisoning by other primarily systemic and hematological agents, accidental (unintentional) (T45.8X1), poisoning by other primarily systemic and hematological agents, intentional self-harm (T45.8X2), poisoning by other primarily systemic and hematological agents, assault (T45.8X3), poisoning by other primarily systemic and hematological agents, undetermined (T45.8X4) and underdosing of other primarily systemic and hematological agents (T45.8X6).
Codes in this range require a 7th character: A for initial encounter, D for subsequent encounter and S for sequela. Use placeholder "X" characters to fill any empty positions before the 7th character.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
7th character
The appropriate 7th character is to be added to each code from category T45
Notes that apply from higher levels
Instructions written at a parent level also apply to T45.8X5.
Broader instructions also apply from T36-T50 Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances and Chapter 19: Injury, poisoning and certain other consequences of external causes.
Table of Drugs & Neoplasms entries
- Albumin › bovine — Adverse effect
- Albumin › human serum — Adverse effect
- Albumin › human serum › salt-poor — Adverse effect
- Albumin › normal human serum — Adverse effect
- Aminoethylisothiourium — Adverse effect
- Antagonist › heavy metal — Adverse effect
- Anti-anemic (drug) (preparation) — Adverse effect
- Antidote NEC › heavy metal — Adverse effect
- Antihemophilic › factor — Adverse effect
- Antihemophilic › fraction — Adverse effect
- Antihemophilic › human plasma — Adverse effect
- BAL — Adverse effect
- Blood (derivatives) (natural) (plasma) (whole) — Adverse effect
- Blood (derivatives) (natural) (plasma) (whole) › dried — Adverse effect
- Blood (derivatives) (natural) (plasma) (whole) › expander NEC — Adverse effect
- Blood (derivatives) (natural) (plasma) (whole) › fraction NEC — Adverse effect
- Blood (derivatives) (natural) (plasma) (whole) › substitute (macromolecular) — Adverse effect
- British antilewisite — Adverse effect
- Calcium › disodium edathamil — Adverse effect
- Calcium › disodium edetate — Adverse effect
- Calcium › EDTA — Adverse effect
- Calcium › folinate — Adverse effect
- Calcium › leucovorin — Adverse effect
- Citrovorum (factor) — Adverse effect
- Cobalt (nonmedicinal) (fumes) (industrial) › medicinal (trace) (chloride) — Adverse effect
- Copper (dust) (fumes) (nonmedicinal) NEC › medicinal (trace) — Adverse effect
- Cyanocobalamin — Adverse effect
- Deferoxamine — Adverse effect
- Desferrioxamine — Adverse effect
- Dextran (40) (70) (150) — Adverse effect
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about T45.8X5
Is T45.8X5 billable?
- No. T45.8X5 is a header code. Report one of its more specific subcodes instead.