ICD-10-CM 2027
ICD-10 code for ACTH overproduction
From the official ICD-10-CM alphabetic index entry “Overproduction › ACTH”. Page updated September 29, 2026.
About coding ACTH overproduction
The ICD-10-CM code for ACTH overproduction is E27.0 (Other adrenocortical overactivity).
Within E27, choose E27.0 (Other adrenocortical overactivity) only when documentation doesn't support a more specific option: primary adrenocortical insufficiency (E27.1), Addisonian crisis (E27.2), drug-induced adrenocortical insufficiency (E27.3), other and unspecified adrenocortical insufficiency (E27.4), Adrenomedullary hyperfunction (E27.5), other specified disorders of adrenal gland (E27.8) and disorder of adrenal gland, unspecified (E27.9).
Don't report E27.0 together with the conditions in its Excludes1 note: Cushing's syndrome (E24.-).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
Don't confuse with (Excludes1 for E27.0)
- Cushing's syndrome (E24.-)
Common questions about ACTH overproduction ICD-10 codes
What is the ICD-10 code for ACTH overproduction?
- E27.0 — Other adrenocortical overactivity.
Is E27.0 billable?
- Yes. E27.0 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E27.0 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E27.0 as a principal diagnosis.
Is E27.0 a CC or MCC?
- E27.0 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.