ICD-10-CM 2027 diagnosis code
E27.8Other specified disorders of adrenal gland
E27.8 is a valid, billable ICD-10-CM code for other specified disorders of adrenal gland. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.
Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS, effective October 1, 2026. Updated September 29, 2026. About our data
About E27.8
E27.8 is the ICD-10-CM diagnosis code for other specified disorders of adrenal gland. It belongs to category E27 (other disorders of adrenal gland), block E20-E35 (disorders of other endocrine glands) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within E27, choose E27.8 (Other specified disorders of adrenal gland) only when documentation doesn't support a more specific option: other adrenocortical overactivity (E27.0), primary adrenocortical insufficiency (E27.1), Addisonian crisis (E27.2), drug-induced adrenocortical insufficiency (E27.3), other and unspecified adrenocortical insufficiency (E27.4), Adrenomedullary hyperfunction (E27.5) and disorder of adrenal gland, unspecified (E27.9).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Before ICD-10, this condition was coded in ICD-9-CM as 255.8 (other specified disorders of adrenal glands).
Coding notes
- Abnormality of cortisol-binding globulin
Notes that apply from higher levels
Instructions written at a parent level also apply to E27.8.
Broader instructions also apply from E20-E35 Disorders of other endocrine glands and Chapter 4: Endocrine, nutritional and metabolic diseases.
Alphabetic index entries
22 entriesTerms in the official ICD-10-CM index that lead to E27.8.
- Abnormal, abnormality, abnormalities › cortisol-binding globulin
- Abnormal, abnormality, abnormalities › globulin › cortisol-binding
- Abscess (connective tissue) (embolic) (fistulous) (infective) (metastatic) (multiple) (pernicious) (pyogenic) (septic) › adrenal (capsule) (gland)
- Abscess (connective tissue) (embolic) (fistulous) (infective) (metastatic) (multiple) (pernicious) (pyogenic) (septic) › suprarenal (capsule) (gland)
- Adrenalitis, adrenitis
- Cyst (colloid) (mucous) (simple) (retention) › adrenal gland
- Cyst (colloid) (mucous) (simple) (retention) › suprarenal gland
- Degeneration, degenerative › adrenal (capsule) (fatty) (gland) (hyaline) (infectional)
- Degeneration, degenerative › suprarenal (capsule) (gland)
- Disease, diseased › adrenal (capsule) (cortex) (gland) (medullary) › specified NEC
- Disease, diseased › suprarenal (capsule) (gland) › specified NEC
- Disorder (of) › adrenal (capsule) (gland) (medullary) › specified NEC
- Fibrosis, fibrotic › adrenal (gland)
- Hemorrhage, hemorrhagic (concealed) › adrenal (capsule) (gland) › medulla
- Hyperplasia, hyperplastic › adrenal (capsule) (cortex) (gland)
- Hyperplasia, hyperplastic › suprarenal capsule (gland)
- Hypertrophy, hypertrophic › adrenal cortex
- Hypertrophy, hypertrophic › suprarenal cortex (gland)
- Inflammation, inflamed, inflammatory (with exudation) › adrenal (gland)
- Inflammation, inflamed, inflammatory (with exudation) › suprarenal (gland)
- Obesity › adrenal
- Sclerosis, sclerotic › adrenal (gland)
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 10 · Endocrine, Nutritional and Metabolic Diseases and Disorders
ICD-9-CM equivalent
Converter →- 255.8Other specified disorders of adrenal glandsapproximate
From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about E27.8
Is E27.8 billable?
- Yes. E27.8 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E27.8 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E27.8 as a principal diagnosis.
Is E27.8 a CC or MCC?
- No. E27.8 is neither a CC nor an MCC under MS-DRG v44.0.
What DRG does E27.8 group to?
- E27.8 is used in the MS-DRG v44.0 logic for MS-DRG 643 (Endocrine Disorders with MCC), MS-DRG 644 (Endocrine Disorders with CC) and MS-DRG 645 (Endocrine Disorders without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.
What is the ICD-9 code for E27.8?
- The CMS General Equivalence Mappings map E27.8 to ICD-9-CM 255.8.