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ICD-10-CM 2027

ICD-10 code for amyloid heart

E85.4

Organ-limited amyloidosis

✓ Billable / specificCC — complication/comorbidity

From the official ICD-10-CM alphabetic index entry “Amyloid heart (disease)”. Page updated September 29, 2026.

About coding amyloid heart

The ICD-10-CM code for amyloid heart is E85.4 (Organ-limited amyloidosis).

Within E85 (amyloidosis), E85.4 is specifically for Organ-limited amyloidosis. Related codes cover Non-neuropathic heredofamilial amyloidosis (E85.0), neuropathic heredofamilial amyloidosis (E85.1), heredofamilial amyloidosis, unspecified (E85.2), secondary systemic amyloidosis (E85.3), other amyloidosis (E85.8) and unspecified (E85.9).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 545 (Connective Tissue Disorders with MCC, relative weight 2.3892), DRG 546 (Connective Tissue Disorders with CC, relative weight 1.1745) and DRG 547 (Connective Tissue Disorders without CC/MCC, relative weight 0.7526), in MDC 08 (Diseases and Disorders of the Musculoskeletal System and Connective Tissue), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

Common questions about amyloid heart ICD-10 codes

What is the ICD-10 code for amyloid heart?

E85.4 — Organ-limited amyloidosis.

Is E85.4 billable?

Yes. E85.4 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E85.4 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict E85.4 as a principal diagnosis.

Is E85.4 a CC or MCC?

E85.4 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.