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ICD-10-CM 2027 diagnosis code

E85.3Secondary systemic amyloidosis

✓ Billable / specificCC — complication/comorbidity

E85.3 is a valid, billable ICD-10-CM code for secondary systemic amyloidosis. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E85.3

E85.3 is the ICD-10-CM diagnosis code for secondary systemic amyloidosis. It belongs to category E85 (amyloidosis), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E85 (amyloidosis), E85.3 is specifically for secondary systemic amyloidosis. Related codes cover Non-neuropathic heredofamilial amyloidosis (E85.0), neuropathic heredofamilial amyloidosis (E85.1), heredofamilial amyloidosis, unspecified (E85.2), Organ-limited amyloidosis (E85.4), other amyloidosis (E85.8) and unspecified (E85.9).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 545 (Connective Tissue Disorders with MCC, relative weight 2.3892), DRG 546 (Connective Tissue Disorders with CC, relative weight 1.1745) and DRG 547 (Connective Tissue Disorders without CC/MCC, relative weight 0.7526), in MDC 08 (Diseases and Disorders of the Musculoskeletal System and Connective Tissue), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 277.39 (other amyloidosis).

Coding notes

Applicable toConditions and synonyms classified to this code
  • Hemodialysis-associated amyloidosis

Notes that apply from higher levels

Instructions written at a parent level also apply to E85.3.

› From E85 Amyloidosis
Excludes2

Broader instructions also apply from E70-E88 Metabolic disorders and Chapter 4: Endocrine, nutritional and metabolic diseases.

Alphabetic index entries

2 entries

Terms in the official ICD-10-CM index that lead to E85.3.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

ICD-9-CM equivalent

Converter →
  • 277.39Other amyloidosisapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about E85.3

Is E85.3 billable?

Yes. E85.3 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E85.3 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict E85.3 as a principal diagnosis.

Is E85.3 a CC or MCC?

E85.3 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.

What DRG does E85.3 group to?

E85.3 is used in the MS-DRG v44.0 logic for MS-DRG 545 (Connective Tissue Disorders with MCC), MS-DRG 546 (Connective Tissue Disorders with CC) and MS-DRG 547 (Connective Tissue Disorders without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for E85.3?

The CMS General Equivalence Mappings map E85.3 to ICD-9-CM 277.39.