ICD-10-CM 2027
ICD-10 code for antibody immunodeficiency defect
Immunodeficiency with predominantly antibody defects, unspecified
From the official ICD-10-CM alphabetic index entry “Defect, defective › antibody immunodeficiency”. Page updated September 29, 2026.
About coding antibody immunodeficiency defect
The ICD-10-CM code for antibody immunodeficiency defect is D80.9 (Immunodeficiency with predominantly antibody defects, unspecified).
Within D80, choose D80.9 (unspecified) only when documentation doesn't support a more specific option: hereditary hypogammaglobulinemia (D80.0), nonfamilial hypogammaglobulinemia (D80.1), selective deficiency of immunoglobulin A [IgA] (D80.2), selective deficiency of immunoglobulin G [IgG] subclasses (D80.3), selective deficiency of immunoglobulin M [IgM] (D80.4), immunodeficiency with increased immunoglobulin M [IgM] (D80.5), antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia (D80.6), transient hypogammaglobulinemia of infancy (D80.7) and 1 more.
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 808 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC, relative weight 2.1705), DRG 809 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC, relative weight 1.2262) and DRG 810 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC, relative weight 1.075), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about antibody immunodeficiency defect ICD-10 codes
What is the ICD-10 code for antibody immunodeficiency defect?
- D80.9 — Immunodeficiency with predominantly antibody defects, unspecified.
Is D80.9 billable?
- Yes. D80.9 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D80.9 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D80.9 as a principal diagnosis.
Is D80.9 a CC or MCC?
- D80.9 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.