ICD-10-CM 2027 diagnosis code
D80.0Hereditary hypogammaglobulinemia
D80.0 is a valid, billable ICD-10-CM code for hereditary hypogammaglobulinemia. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About D80.0
D80.0 is the ICD-10-CM diagnosis code for hereditary hypogammaglobulinemia. It belongs to category D80 (immunodeficiency with predominantly antibody defects), block D80-D89 (certain disorders involving the immune mechanism) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within D80 (immunodeficiency with predominantly antibody defects), D80.0 is specifically for hereditary hypogammaglobulinemia. Related codes cover nonfamilial hypogammaglobulinemia (D80.1), selective deficiency of immunoglobulin A [IgA] (D80.2), selective deficiency of immunoglobulin G [IgG] subclasses (D80.3), selective deficiency of immunoglobulin M [IgM] (D80.4), immunodeficiency with increased immunoglobulin M [IgM] (D80.5), antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia (D80.6), transient hypogammaglobulinemia of infancy (D80.7), other immunodeficiencies with predominantly antibody defects (D80.8) and 1 more.
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 814 (Reticuloendothelial and Immunity Disorders with MCC, relative weight 2.0729), DRG 815 (Reticuloendothelial and Immunity Disorders with CC, relative weight 1.0444) and DRG 816 (Reticuloendothelial and Immunity Disorders without CC/MCC, relative weight 0.7381), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Before ICD-10, this condition was coded in ICD-9-CM as 279.04 (congenital hypogammaglobulinemia).
Coding notes
- Autosomal recessive agammaglobulinemia (Swiss type)
- X-linked agammaglobulinemia [Bruton] (with growth hormone deficiency)
Notes that apply from higher levels
Instructions written at a parent level also apply to D80.0.
Broader instructions also apply from D80-D89 Certain disorders involving the immune mechanism and Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism.
Alphabetic index entries
14 entriesTerms in the official ICD-10-CM index that lead to D80.0.
- Absence (of) (organ or part) (complete or partial) › gamma globulin in blood › hereditary
- Agammaglobulinemia (acquired (secondary)) (nonfamilial) › autosomal recessive (Swiss type)
- Agammaglobulinemia (acquired (secondary)) (nonfamilial) › Bruton's X-linked
- Agammaglobulinemia (acquired (secondary)) (nonfamilial) › congenital sex-linked
- Agammaglobulinemia (acquired (secondary)) (nonfamilial) › hereditary
- Agammaglobulinemia (acquired (secondary)) (nonfamilial) › Swiss type (autosomal recessive)
- Agammaglobulinemia (acquired (secondary)) (nonfamilial) › X-linked (with growth hormone deficiency) (Bruton)
- Bruton's X-linked agammaglobulinemia
- Deficiency, deficient › gammaglobulin in blood › hereditary
- Hypogammaglobulinemia › hereditary
- Immunodeficiency › autosomal recessive, Swiss type
- Syndrome › antibody deficiency › agammaglobulinemic › hereditary
- Syndrome › antibody deficiency › congenital
- Syndrome › antibody deficiency › hypogammaglobulinemic › hereditary
Codes whose notes reference D80.0
- D81Excludes1
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 16 · Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders
ICD-9-CM equivalent
Converter →- 279.04Congenital hypogammaglobulinemiaexact
From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about D80.0
Is D80.0 billable?
- Yes. D80.0 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D80.0 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D80.0 as a principal diagnosis.
Is D80.0 a CC or MCC?
- D80.0 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.
What DRG does D80.0 group to?
- D80.0 is used in the MS-DRG v44.0 logic for MS-DRG 814 (Reticuloendothelial and Immunity Disorders with MCC), MS-DRG 815 (Reticuloendothelial and Immunity Disorders with CC) and MS-DRG 816 (Reticuloendothelial and Immunity Disorders without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.
What is the ICD-9 code for D80.0?
- The CMS General Equivalence Mappings map D80.0 to ICD-9-CM 279.04.