D80.6Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia

D80.6 is the ICD-10-CM diagnosis code for antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia. It belongs to category D80 (immunodeficiency with predominantly antibody defects), block D80-D89 (certain disorders involving the immune mechanism) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within D80 (immunodeficiency with predominantly antibody defects), D80.6 is specifically for antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia. Related codes cover hereditary hypogammaglobulinemia (D80.0), nonfamilial hypogammaglobulinemia (D80.1), selective deficiency of immunoglobulin A [IgA] (D80.2), selective deficiency of immunoglobulin G [IgG] subclasses (D80.3), selective deficiency of immunoglobulin M [IgM] (D80.4), immunodeficiency with increased immunoglobulin M [IgM] (D80.5), transient hypogammaglobulinemia of infancy (D80.7), other immunodeficiencies with predominantly antibody defects (D80.8) and 1 more.

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 808 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC, relative weight 2.1705), DRG 809 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC, relative weight 1.2262) and DRG 810 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC, relative weight 1.075), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 279.09 (other deficiency of humoral immunity).