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ICD-10-CM 2027

ICD-10 code for beta severe thalassemia

D56.1

Beta thalassemia

✓ Billable / specific

From the official ICD-10-CM alphabetic index entry “Thalassemia (anemia) (disease) › beta (severe)”. Page updated September 29, 2026.

About coding beta severe thalassemia

The ICD-10-CM code for beta severe thalassemia is D56.1 (Beta thalassemia). The official index lists 4 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on D56.1.

Within D56 (thalassemia), D56.1 is specifically for beta thalassemia. Related codes cover alpha thalassemia (D56.0), Delta-beta thalassemia (D56.2), minor (D56.3), hereditary persistence of fetal hemoglobin [HPFH] (D56.4), hemoglobin E-beta thalassemia (D56.5), other thalassemias (D56.8) and unspecified (D56.9).

Don't report D56.1 together with the conditions in its Excludes1 note: beta thalassemia minor (D56.3), beta thalassemia trait (D56.3), delta-beta thalassemia (D56.2), hemoglobin E-beta thalassemia (D56.5) and 1 more.

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

More specific beta severe thalassemia codes (official index)

  • homozygous D56.1 — Beta thalassemia
  • major D56.1 — Beta thalassemia
  • minor D56.3 — Thalassemia minor
  • trait D56.3 — Thalassemia minor

Don't confuse with (Excludes1 for D56.1)

  • beta thalassemia minor (D56.3)
  • beta thalassemia trait (D56.3)
  • delta-beta thalassemia (D56.2)
  • hemoglobin E-beta thalassemia (D56.5)
  • sickle-cell beta thalassemia (D57.4-)

Common questions about beta severe thalassemia ICD-10 codes

What is the ICD-10 code for beta severe thalassemia?

D56.1 — Beta thalassemia. More specific codes apply when the documentation supports them: D56.1, D56.1, D56.3, D56.3.

What is the ICD-10 code for homozygous beta severe thalassemia?

D56.1 — Beta thalassemia.

What is the ICD-10 code for major beta severe thalassemia?

D56.1 — Beta thalassemia.

What is the ICD-10 code for minor beta severe thalassemia?

D56.3 — Thalassemia minor.

What is the ICD-10 code for trait beta severe thalassemia?

D56.3 — Thalassemia minor.

Is D56.1 billable?

Yes. D56.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can D56.1 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict D56.1 as a principal diagnosis.

Is D56.1 a CC or MCC?

No. D56.1 is neither a CC nor an MCC under MS-DRG v44.0.